Publications — Radcliffe Department of Medicine

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GTP cyclohydrolase drives breast cancer development and promotes EMT in an enzyme-independent manner.

Wang Z. et al, (2023), Cancer Res

Operative ubiquitin-specific protease 22 deubiquitination confers a more invasive phenotype to cholangiocarcinoma.

Tian Y. et al, (2021), Cell Death Dis, 12

GTP cyclohydrolase accelerates tumor progression through interaction with angiopoietin-1 in stromal fibroblasts and activation of Tie2 on breast cancer cells

CAI S. et al, (2017)

GTP cyclohydrolase as a novel mechanism for tumour growth

CAI S. et al, (2017)

Paracrine effect of GTP cyclohydrolase and angiopoietin-1 interaction in stromal fibroblasts on tumor Tie2 activation and breast cancer growth.

Chen L. et al, (2016), Oncotarget, 7, 9353 - 9367

Cord and cord blood-derived endothelial cells

Watt SM. et al, (2014), Cord Blood Stem Cells Medicine, 49 - 61

Effect of trans10, cis12-conjugated linoleic acid on glucose consumption of insulin resistance chang liver cells

Li C. et al, (2011), Journal of Food Biochemistry, 35, 1593 - 1602

Roles of tetrahydrobiopterin in promoting tumor angiogenesis.

Chen L. et al, (2010), Am J Pathol, 177, 2671 - 2680

Tetrahydrobiopterin (BH4), a cofactor for nNOS, restores gastric emptying and nNOS expression in female diabetic rats.

Gangula PRR. et al, (2010), Am J Physiol Gastrointest Liver Physiol, 298, G692 - G699

Methods for lymphatic vessel culture and gene transfection.

Gashev AA. et al, (2009), Microcirculation, 16, 615 - 628

Reduced vascular NO bioavailability in diabetes increases platelet activation in vivo.

Schäfer A. et al, (2004), Arterioscler Thromb Vasc Biol, 24, 1720 - 1726

Impaired regulation of neuronal nitric oxide synthase and heart rate during exercise in mice lacking one nNOS allele.

Danson EJF. et al, (2004), J Physiol, 558, 963 - 974

Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.

Alp NJ. et al, (2003), J Clin Invest, 112, 725 - 735

Adenoviral-mediated delivery of a viral chemokine binding protein blocks CC-chemokine activity in vitro and in vivo.

Bursill CA. et al, (2003), Immunobiology, 207, 187 - 196

Neuronal nitric oxide synthase gene transfer promotes cardiac vagal gain of function.

Mohan RM. et al, (2002), Circ Res, 91, 1089 - 1091

GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisation.

Cai S. et al, (2002), Cardiovasc Res, 55, 838 - 849

Nitric oxide synthase (nNOS) gene transfer modifies venous bypass graft remodeling: effects on vascular smooth muscle cell differentiation and superoxide production.

West NE. et al, (2001), Circulation, 104, 1526 - 1532

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