Publications — Radcliffe Department of Medicine

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Multiplex-GAM: genome-wide identification of chromatin contacts yields insights overlooked by Hi-C.

Beagrie RA. et al, (2023), Nat Methods

Gene silencing dynamics are modulated by transiently active regulatory elements.

Vermunt MW. et al, (2023), Mol Cell, 83, 715 - 730.e6

Pathogenic human variant that dislocates GATA2 zinc fingers disrupts hematopoietic gene expression and signaling networks.

Jung MM. et al, (2023), J Clin Invest

Scalable in vitro production of defined mouse erythroblasts.

Francis HS. et al, (2022), PLoS One, 17

Making connections: enhancers in cellular differentiation

Herrmann JC. et al, (2021), Trends in Genetics

Recapitulation of erythropoiesis in congenital dyserythropoietic anaemia type I (CDA-I) identifies defects in differentiation and nucleolar abnormalities.

Scott C. et al, (2021), Haematologica, 106, 2960 - 2970

Reactivation of a developmentally silenced embryonic globin gene.

King AJ. et al, (2021), Nat Commun, 12

The mouse alpha-globin cluster: a paradigm for studying genome regulation and organization.

Oudelaar AM. et al, (2021), Curr Opin Genet Dev, 67, 18 - 24

Enhancers predominantly regulate gene expression during differentiation via transcription initiation.

Larke MSC. et al, (2021), Mol Cell, 81, 983 - 997.e7

High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale.

Downes DJ. et al, (2021), Nat Commun, 12

Hypoxia Induces Transcriptional and Translational Downregulation of the Type I IFN Pathway in Multiple Cancer Cell Types.

Miar A. et al, (2020), Cancer Res, 80, 5245 - 5256

Multiplex-GAM: genome-wide identification of chromatin contacts yields insights not captured by Hi-C

Beagrie RA. et al, (2020)

Dynamics of the 4D genome during in vivo lineage specification and differentiation.

Oudelaar AM. et al, (2020), Nat Commun, 11

Dissection of the 4D chromatin structure of the α-globin locus through in vivo erythroid differentiation with extreme spatial and temporal resolution

Oudelaar M. et al, (2019)

Hypoxia induces transcriptional and translational downregulation of the type I interferon (IFN) pathway in multiple cancer cell types

Miar A. et al, (2019)

Modelling erythropoiesis in congenital dyserythropoietic anaemia type I (CDA-I)

Scott C. et al, (2019)

Cell cycle: Continuous chromatin changes.

Beagrie RA. and Pombo A., (2017), Nature, 547, 34 - 35

Complex multi-enhancer contacts captured by genome architecture mapping.

Beagrie RA. et al, (2017), Nature, 543, 519 - 524

GAMtools: an automated pipeline for analysis of Genome Architecture Mapping data

Beagrie R. and Schueler M., (2017)

Examining Topological Domain Influence on Enhancer Function.

Beagrie RA. and Pombo A., (2016), Dev Cell, 39, 523 - 524

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