Publications — Radcliffe Department of Medicine

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α-cell electrophysiology and the regulation of glucagon secretion.

Gao R. et al, (2023), J Endocrinol, 258

Loss of tetraspanin-7 expression reduces pancreatic beta-cell exocytosis Ca2+ sensitivity but has limited effect on systemic metabolism.

McLaughlin K. et al, (2022), Diabet Med

A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic β-cells.

Ye Y. et al, (2022), Nat Commun, 13

Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion.

Veprik A. et al, (2022), Commun Biol, 5

Temporal metabolic and transcriptomic characteristics crossing islets and liver reveal dynamic pathophysiology in diet-induced diabetes.

Gao R. et al, (2021), iScience, 24

δ-Cells: The Neighborhood Watch in the Islet Community.

Gao R. et al, (2021), Biology (Basel), 10

"Take Me To Your Leader": An Electrophysiological Appraisal of the Role of Hub Cells in Pancreatic Islets.

Satin LS. et al, (2020), Diabetes, 69, 830 - 836

Somatostatin secretion by Na+-dependent Ca2+-induced Ca2+ release in pancreatic delta-cells.

Vergari E. et al, (2020), Nat Metab, 2, 32 - 40

Glucose stimulates somatostatin secretion in pancreatic δ-cells by cAMP-dependent intracellular Ca2+ release.

Denwood G. et al, (2019), J Gen Physiol, 151, 1094 - 1115

Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production.

Knudsen JG. et al, (2019), Cell Metab, 29, 430 - 442.e4

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion.

Vergari E. et al, (2019), Nat Commun, 10

α-cell glucokinase suppresses glucose-regulated glucagon secretion.

Basco D. et al, (2018), Nat Commun, 9

Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy.

Babinsky VN. et al, (2017), Endocrinology, 158, 2486 - 2502

Functional identification of islet cell types by electrophysiological fingerprinting.

Briant LJB. et al, (2017), J R Soc Interface, 14

Glucagon secretion from pancreatic α-cells.

Briant L. et al, (2016), Ups J Med Sci, 121, 113 - 119

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.

Arredouani A. et al, (2015), J Biol Chem, 290, 21376 - 21392

Alpha-, Delta- and PP-cells: Are They the Architectural Cornerstones of Islet Structure and Co-ordination?

Brereton MF. et al, (2015), J Histochem Cytochem, 63, 575 - 591

Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.

Zhang Q. et al, (2014), J Physiol, 592, 4677 - 4696

ATP-regulated potassium channels and voltage-gated calcium channels in pancreatic alpha and beta cells: similar functions but reciprocal effects on secretion.

Rorsman P. et al, (2014), Diabetologia, 57, 1749 - 1761

Elevation of cAMP promotes an Epac2 dependent, L-type Ca2+-channel coupled, Ca2+-induced Ca2+ release in mouse alpha cells

Zhang Q. et al, (2014), DIABETOLOGIA, 57, S253 - S253

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