Publications — Radcliffe Department of Medicine

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PAF1 and FACT cooperate with MLL-AF4 to drive enhancer activity in leukemia

Crump NT. et al, (2022)

Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart.

Hulikova A. et al, (2022), Basic Res Cardiol, 117

Potent, p53-independent induction of NOXA sensitizes MLL-rearranged B-cell acute lymphoblastic leukemia cells to venetoclax.

Fidyt K. et al, (2022), Oncogene, 41, 1600 - 1609

A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program

Rice S. et al, (2021), Nature Communications, 12

Defining genome architecture at base-pair resolution.

Hua P. et al, (2021), Nature, 595, 125 - 129

A KMT2A-AFF1 gene regulatory network highlights the role of core transcription factors and reveals the regulatory logic of key downstream target genes.

Harman JR. et al, (2021), Genome Res

BET inhibition disrupts transcription but retains enhancer-promoter contact.

Crump NT. et al, (2021), Nat Commun, 12

H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells.

Godfrey L. et al, (2021), Leukemia, 35, 90 - 106

Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs.

O'Byrne S. et al, (2019), Blood, 134, 1059 - 1071

Why are so many MLL lysine methyltransferases required for normal mammalian development?

Crump NT. and Milne TA., (2019), Cell Mol Life Sci, 76, 2885 - 2898

DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation.

Godfrey L. et al, (2019), Nat Commun, 10

Live-cell studies of p300/CBP histone acetyltransferase activity and inhibition.

Dancy BM. et al, (2012), Chembiochem, 13, 2113 - 2121

Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP.

Crump NT. et al, (2011), Proc Natl Acad Sci U S A, 108, 7814 - 7819

Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor.

Bowers EM. et al, (2010), Chem Biol, 17, 471 - 482

Reconstitution and analysis of the multienzyme Escherichia coli RNA degradosome.

Worrall JAR. et al, (2008), J Mol Biol, 382, 870 - 883

Stress-activated MAP kinases in chromatin and transcriptional complexes

Crump NT. et al, (2008), Topics in Current Genetics, 20, 283 - 297

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