Publications — Radcliffe Department of Medicine

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Potent, p53-independent induction of NOXA sensitizes MLL-rearranged B-cell acute lymphoblastic leukemia cells to venetoclax.

Fidyt K. et al, (2022), Oncogene, 41, 1600 - 1609

Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development.

Owens DDG. et al, (2022), Nat Commun, 13

The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition.

Azzoni E. et al, (2021), Cell Rep, 37

A KMT2A-AFF1 gene regulatory network highlights the role of core transcription factors and reveals the regulatory logic of key downstream target genes.

Harman JR. et al, (2021), Genome Res

H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells.

Godfrey L. et al, (2021), Leukemia, 35, 90 - 106

Microhomologies are prevalent at Cas9-induced larger deletions.

Owens DDG. et al, (2019), Nucleic Acids Res, 47, 7402 - 7417

Chemotherapy-induced cachexia dysregulates hypothalamic and systemic lipoamines and is attenuated by cannabigerol.

Brierley DI. et al, (2019), Journal of cachexia, sarcopenia and muscle, 10, 844 - 859

DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation.

Godfrey L. et al, (2019), Nat Commun, 10

Kit ligand has a critical role in mouse yolk sac and aorta-gonad-mesonephros hematopoiesis.

Azzoni E. et al, (2018), EMBO Rep, 19

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