Loop extrusion by cohesin plays a key role in enhancer-activated gene expression during differentiation
Preprint
Stolper RJ. et al, (2023)
Author Correction: Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture.
Journal article
Downes DJ. et al, (2023), Nat Protoc
Chromatin remodeller Chd7 is developmentally regulated in the neural crest by tissue-specific transcription factors
Preprint
Williams R. et al, (2022)
LanceOtron: a deep learning peak caller for genome sequencing experiments.
Journal article
Hentges LD. et al, (2022), Bioinformatics
Chromatin interaction maps identify Wnt responsive cis-regulatory elements coordinating Paupar-Pax6 expression in neuronal cells.
Journal article
Pavlaki I. et al, (2022), PLoS genetics, 18
Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture.
Journal article
Downes DJ. et al, (2022), Nat Protoc
Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cells
Preprint
Torres J. et al, (2022)
Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus
Journal article
DOWNES D. et al, (2021), Nature Genetics
Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus.
Journal article
Downes DJ. et al, (2021), Nat Genet, 53, 1606 - 1615
Making connections: enhancers in cellular differentiation
Journal article
Herrmann JC. et al, (2021), Trends in Genetics
Recapitulation of erythropoiesis in congenital dyserythropoietic anaemia type I (CDA-I) identifies defects in differentiation and nucleolar abnormalities.
Journal article
Scott C. et al, (2021), Haematologica, 106, 2960 - 2970
Reactivation of a developmentally silenced embryonic globin gene.
Journal article
King AJ. et al, (2021), Nat Commun, 12
Defining genome architecture at base-pair resolution.
Journal article
Hua P. et al, (2021), Nature, 595, 125 - 129
A gain-of-function single nucleotide variant creates a new promoter which acts as an orientation-dependent enhancer-blocker.
Journal article
Bozhilov YK. et al, (2021), Nat Commun, 12
Multi Locus View: an extensible web-based tool for the analysis of genomic data.
Journal article
Sergeant MJ. et al, (2021), Commun Biol, 4
Enzyme replacement therapy and hematopoietic stem cell transplant: a new paradigm of treatment in Wolman disease.
Journal article
Potter JE. et al, (2021), Orphanet J Rare Dis, 16
Chromatin interaction maps identify Wnt responsive cis-regulatory elements coordinating Paupar-Pax6 expression in neuronal cells
Journal article
Pavlaki I. et al, (2021)
Fra-1 regulates its target genes via binding to remote enhancers without exerting major control on chromatin architecture in triple negative breast cancers.
Journal article
Bejjani F. et al, (2021), Nucleic Acids Res, 49, 2488 - 2508
Enhancers predominantly regulate gene expression during differentiation via transcription initiation.
Journal article
Larke MSC. et al, (2021), Mol Cell, 81, 983 - 997.e7
Genetic and functional insights into CDA-I prevalence and pathogenesis.
Journal article
Olijnik A-A. et al, (2021), J Med Genet, 58, 185 - 195