Publications — Radcliffe Department of Medicine

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The MITF regulatory network in melanoma.

Chauhan JS. et al, (2022), Pigment Cell Melanoma Res

TBX2 controls a proproliferative gene expression program in melanoma.

Lu S. et al, (2021), Genes Dev, 35, 1657 - 1677

TOP1 modulation during melanoma progression and in adaptative resistance to BRAF and MEK inhibitors.

Oliveira ÉAD. et al, (2021), Pharmacol Res, 173

TBX3 Promotes Melanoma Migration by Transcriptional Activation of ID1, which Prevents Activation of E-Cadherin by MITF.

Peres J. et al, (2021), J Invest Dermatol, 141, 2250 - 2260.e2

Mitochondrial Inhibitor Atovaquone Increases Tumor Oxygenation and Inhibits Hypoxic Gene Expression in Patients with Non-Small Cell Lung Cancer.

Skwarski M. et al, (2021), Clin Cancer Res, 27, 2459 - 2469

Paradoxical activation of AMPK by glucose drives selective EP300 activity in colorectal cancer.

Gutiérrez-Salmerón M. et al, (2020), PLoS Biol, 18

Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity.

Vivas-García Y. et al, (2020), Mol Cell, 77, 120 - 137.e9

ABCB5 is activated by MITF and β-catenin and is associated with melanoma differentiation.

Louphrasitthiphol P. et al, (2020), Pigment Cell Melanoma Res, 33, 112 - 118

MITF controls the TCA cycle to modulate the melanoma hypoxia response.

Louphrasitthiphol P. et al, (2019), Pigment Cell Melanoma Res, 32, 792 - 808

E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition.

Burdova K. et al, (2019), EMBO J, 38

BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma.

Herbert K. et al, (2019), Genes Dev, 33, 310 - 332

RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73.

Papaspyropoulos A. et al, (2018), Nat Commun, 9

Targeting the hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cells.

Faião-Flores F. et al, (2017), Oncogene, 36, 1849 - 1861

Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression.

Kalkavan H. et al, (2017), Nat Commun, 8

NFIB Mediates BRN2 Driven Melanoma Cell Migration and Invasion Through Regulation of EZH2 and MITF.

Fane ME. et al, (2017), EBioMedicine, 16, 63 - 75

Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma.

Falletta P. et al, (2017), Genes Dev, 31, 18 - 33

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