Publications — Radcliffe Department of Medicine

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Enhancers predominantly regulate gene expression during differentiation via transcription initiation.

Larke MSC. et al, (2021), Mol Cell

The relationship between genome structure and function.

Oudelaar AM. and Higgs DR., (2020), Nat Rev Genet

The mouse alpha-globin cluster: a paradigm for studying genome regulation and organization.

Oudelaar AM. et al, (2020), Curr Opin Genet Dev, 67, 18 - 24

Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder.

Long HK. et al, (2020), Cell Stem Cell, 27, 765 - 783.e14

Recapitulation of erythropoiesis in congenital dyserythropoietic anaemia type I (CDA-I) identifies defects in differentiation and nucleolar abnormalities.

Scott C. et al, (2020), Haematologica, Online ahead of print

A remarkable case of HbH disease illustrates the relative contributions of the α-globin enhancers to gene expression.

Badat M. et al, (2020), Blood

An evolutionarily ancient mechanism for regulation of hemoglobin expression in vertebrate red cells.

Miyata M. et al, (2020), Blood, 136, 269 - 278

Genetic and functional insights into CDA-I prevalence and pathogenesis.

Olijnik A-A. et al, (2020), J Med Genet

ATR-16 syndrome: mechanisms linking monosomy to phenotype.

Babbs C. et al, (2020), J Med Genet, 57, 414 - 421

Dynamics of the 4D genome during in vivo lineage specification and differentiation.

Oudelaar AM. et al, (2020), Nat Commun, 11

Variable cells with identical genetic codes.

Babbs C. and Higgs DR., (2020), Blood, 135, 1921 - 1922

Enhancer-promoter interactions and transcription.

Higgs DR., (2020), Nat Genet, 52, 470 - 471

An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis.

Xiang G. et al, (2020), Genome Res

A Dynamic Folded Hairpin Conformation Is Associated with α-Globin Activation in Erythroid Cells.

Chiariello AM. et al, (2020), Cell Rep, 30, 2125 - 2135.e5

Systematic integration of GATA transcription factors and epigenomes via IDEAS paints the regulatory landscape of hematopoietic cells.

Hardison RC. et al, (2020), IUBMB Life, 72, 27 - 38

A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus.

Oudelaar AM. et al, (2019), Nature communications, 10

An integrated platform to systematically identify causal variants and genes for polygenic human traits

Downes D. et al, (2019)

Synergistic silencing of α-globin and induction of γ-globin by histone deacetylase inhibitor, vorinostat as a potential therapy for β-thalassaemia.

Mettananda S. et al, (2019), Sci Rep, 9

The bipartite TAD organization of the X-inactivation center ensures opposing developmental regulation of Tsix and Xist.

van Bemmel JG. et al, (2019), Nat Genet, 51, 1024 - 1034

Single-Cell Proteomics Reveal that Quantitative Changes in Co-expressed Lineage-Specific Transcription Factors Determine Cell Fate.

Palii CG. et al, (2019), Cell Stem Cell, 24, 812 - 820.e5

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