Publications — Radcliffe Department of Medicine

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Electrophysiological characterisation of iPSC-derived human β-like cells and an SLC30A8 disease model.

Jaffredo M. et al, (2024), Diabetes

Platelet-derived lipids promote insulin secretion of pancreatic β cells.

Karwen T. et al, (2023), EMBO Mol Med

Electrophysiological characterisation of iPSC-derived human β-like cells and anSLC30A8disease model.

Jaffredo M. et al, (2023)

Loss of tetraspanin-7 expression reduces pancreatic beta-cell exocytosis Ca2+ sensitivity but has limited effect on systemic metabolism.

McLaughlin K. et al, (2022), Diabet Med

Erratum: Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion (Cell Reports (2021) 34(5), (S2211124721000164), (10.1016/j.celrep.2021.108703))

Hu M. et al, (2021), Cell Reports, 34

Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion.

Hu M. et al, (2021), Cell Rep, 34

Author Correction: Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics.

Ast J. et al, (2020), Nat Commun, 11

A CRISPR/Cas9 genome editing pipeline in the EndoC-βH1 cell line to study genes implicated in beta cell function

Grotz AK. et al, (2020), Wellcome Open Research, 4, 150 - 150

Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics.

Ast J. et al, (2020), Nat Commun, 11

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion.

Dwivedi OP. et al, (2019), Nat Genet, 51, 1596 - 1606

A CRISPR/Cas9 genome editing pipeline in the EndoC-βH1 cell line to study genes implicated in beta cell function

Grotz A. et al, (2019)

Investigating a Candidate Causal Allele in Type 2 Diabetes Susceptibility Gene PAM as a Cause of Neonatal Diabetes Mellitus

Sengupta S. et al, (2019), DIABETES, 68

The transmembrane domain of the SNARE protein VAMP2 is highly sensitive to its lipid environment.

Fezoua-Boubegtiten Z. et al, (2019), Biochim Biophys Acta Biomembr, 1861, 670 - 676

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion.

Vergari E. et al, (2019), Nat Commun, 10

A CRISPR/Cas9 genome editing pipeline in the EndoC-βH1 cell line to study genes implicated in beta cell function.

Grotz AK. et al, (2019), Wellcome Open Research, 4

LUXendins reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

Ast J. et al, (2019)

Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells.

Hastoy B. et al, (2018), Sci Rep, 8

Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells.

Thomsen SK. et al, (2018), Nat Genet, 50, 1122 - 1131

NKX6.1 induced pluripotent stem cell reporter lines for isolation and analysis of functionally relevant neuronal and pancreas populations.

Gupta SK. et al, (2018), Stem Cell Res, 29, 220 - 231

Type-2 Diabetes - A Fusion Pore Disease?

Rorsman P. et al, (2018), BIOPHYSICAL JOURNAL, 114, 10A - 10A

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