Publications — Radcliffe Department of Medicine

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Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion.

Hu M. et al, (2021), Cell Rep, 34

Author Correction: Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics.

Ast J. et al, (2020), Nat Commun, 11

A CRISPR/Cas9 genome editing pipeline in the EndoC-βH1 cell line to study genes implicated in beta cell function

Grotz AK. et al, (2020), Wellcome Open Research, 4, 150 - 150

Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics.

Ast J. et al, (2020), Nat Commun, 11

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion.

Dwivedi OP. et al, (2019), Nat Genet

A CRISPR/Cas9 genome editing pipeline in the EndoC-βH1 cell line to study genes implicated in beta cell function

Grotz A. et al, (2019)

Investigating a Candidate Causal Allele in Type 2 Diabetes Susceptibility Gene PAM as a Cause of Neonatal Diabetes Mellitus

Sengupta S. et al, (2019), DIABETES, 68

The transmembrane domain of the SNARE protein VAMP2 is highly sensitive to its lipid environment.

Fezoua-Boubegtiten Z. et al, (2019), Biochim Biophys Acta Biomembr, 1861, 670 - 676

LUXendins reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

Ast J. et al, (2019)

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion.

Vergari E. et al, (2019), Nat Commun, 10

A CRISPR/Cas9 genome editing pipeline in the EndoC-βH1 cell line to study genes implicated in beta cell function.

Grotz AK. et al, (2019), Wellcome Open Research, 4

Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells.

Hastoy B. et al, (2018), Sci Rep, 8

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

Dwivedi OP. et al, (2018)

Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells.

Thomsen SK. et al, (2018), Nat Genet, 50, 1122 - 1131

NKX6.1 induced pluripotent stem cell reporter lines for isolation and analysis of functionally relevant neuronal and pancreas populations.

Gupta SK. et al, (2018), Stem Cell Res, 29, 220 - 231

Type-2 Diabetes - A Fusion Pore Disease?

Rorsman P. et al, (2018), BIOPHYSICAL JOURNAL, 114, 10A - 10A

AP2σ Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity.

Gorvin CM. et al, (2018), Cell Rep, 22, 1054 - 1066

Fusion pore in exocytosis: More than an exit gate? A β-cell perspective.

Hastoy B. et al, (2017), Cell Calcium, 68, 45 - 61

The Calcium-Sensing Receptor, a Class C GPCR, Spatially-Directs G-protein Selectivity via Endosomal Signaling.

Gorvin C. et al, (2017), JOURNAL OF BONE AND MINERAL RESEARCH, 32, S8 - S8

Electrophysiological properties of human β-cell lines EndoC-βH1 and -βH2 conform with human β-cells

Hastoy B. et al, (2017)

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