Dr Thomas A. Agbaedeng
BSc (Hons), PhD
NOVO NORDISK POSTDOCTORAL RESEARCH FELLOW
I completed my PhD at University of Adelaide, Australia, where I used a multimodal approach of meta-analysis and pre-clinical experimental models to characterise the arrhythmogenicity of epicardial fat. My PhD work led to multiple awards, including the Young Investigator Award (1st Prize) at the European Heart Rhythm Association Congress, Spain. I then began a postdoctoral position at The University of Adelaide in 2019. In 2020, I was awarded a Visiting Fellowship at Amsterdam UMC (Netherlands) to study proteomic phenotyping of epicardial fat in atrial fibrillation, funded by the Cardiac Society of Australia and New Zealand. In 2021, I was awarded University of Adelaide’s Emerging Leaders Grant for an in vitro study of cardiac fibrogenesis.
I started my Novo Nordisk Postdoctoral Research Fellowship with Professor Chris O’Callaghan (Nuffield Department of Medicine, NDM) and Dr Joanna Howson (NNRCO) in November 2021. The project builds on prior work on lipid-mediated genome-wide chromatin remodelling. I will use trans-omics approaches to develop a genome-wide map of the oxidized LDL-cholesterol-induced chromatin changes in coronary vascular cells. This will be integrated with GWAS information for cardiometabolic traits to identify new drug targets. These variants will be further tested and validated via focused in vitro experiments using cellular and molecular biology techniques.
Accelerated biological aging secondary to cardiometabolic risk factors is a predictor of cardiovascular mortality: a systematic review and meta-analysis
Emami M. et al, (2021), Canadian Journal of Cardiology
Gut microbiota, dysbiosis and atrial fibrillation. Arrhythmogenic mechanisms and potential clinical implications
Gawałko M. et al, (2021), Cardiovascular Research
Polygenic risk score and coronary artery disease: A meta-analysis of 979,286 participant data
Agbaedeng TA. et al, (2021), Atherosclerosis, 333, 48 - 55
The Role of MSC Therapy in Attenuating the Damaging Effects of the Cytokine Storm Induced by COVID-19 on the Heart and Cardiovascular System
Ellison-Hughes GM. et al, (2020), Frontiers in Cardiovascular Medicine, 7
Vascular Manifestations of COVID-19 – Thromboembolism and Microvascular Dysfunction
Roberts KA. et al, (2020), Frontiers in Cardiovascular Medicine, 7