My research is focused upon developing gene editing tools to tackle the genetic variants which underpin inherited cardiomyopathies. Building upon past research into the genetics and molecular mechanisms of hypertrophic (HCM) and dilated cardiomyopathies (DCM), my aim is to develop curative genetic therapies for these diseases. My work is based on cellular models for inherited cardiomyopathies. Using human induced pluripotent stem-cells and CRISPR/Cas9 engineering, I generate beating sheets of cardiomyocytes with disease-causing variants. These cells then allow me to test genetic therapies on a model of diseased heart muscle in a dish.
My work is supported by the Medical Research Council, Radcliffe Department of Medicine and British Heart Foundation.