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Richard Yan-Do

Novo Nordisk Postdoctoral Research Fellow

I completed my PhD in Pharmacology at the University of Alberta (Edmonton, Canada) under the supervision of Professor Patrick MacDonald and Assistant Professor Matthias Braun. During my PhD, I studied the glycine receptor and its role in paracrine and autocrine signalling in human pancreatic islets. I revealed the mechanism by which glycine stimulates insulin secretion in human islets and I discovered how glycine signalling becomes impaired in diabetes.

I was awarded the Novo Nordisk Postdoctoral Research fellowship to work with Professor Cecilia Lindgren from the Big Data Institute, starting in January 2019. The focus of my fellowship is to dissect the functional effects of genetic variants on obesity related traits. I will combine genetic, experimental, and clinical data to characterise genetic variants and develop a model to predict variant function. Top hits from the model will be followed up in the lab to discover novel pathways by which genetic variants affect obesity.