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Randeep Singh

PhD, MSc, BSc (Hons)

Postdoctoral Scientist

Skin Inflammation

I obtained my BSc (Hons) in Biochemistry before completing an MSc in Molecular Medicine. I developed an interest in T cell biology and went on to obtain my PhD, where I investigated the role of the transcription factor Egr2 in regulating T cell responses in viral infection.

My work in Professor Graham Ogg's group focuses on understanding molecular pathways that cause skin inflammation, with a particular focus on lipid antigens, which can be presented to T cells by HLA-I like molecule CD1a. Langerhans cells (LCs) are specialized populations of dendritic cells found in the epidermis of the skin and have high expression of CD1a. CD1a-restricted T cell activation is now known to contribute to skin inflammation, which makes CD1a mediated T cell responses an important target for immunotherapy for patients with skin inflammatory conditions, such as, atopic dermatitis (AD) and psoriasis. Our group’s research focuses on identifying novel lipid antigens that mediate T cells responses in skin. Findings from this research therefore can provide new pathways for therapeutic intervention.