Associate Professor of Cardiovascular Medicine
- Consultant Cardiologist
The focus of our work is on understanding ischemia-reperfusion injury and how this can be reduced particularly by remote preconditioning. In addition to understanding heart muscle responses, we are also interested in blood vessel injury, particularly the microcirculation.
We have developed a number of models to study ischemia-reperfusion injury in humans including ex-vivo and in-vivo models of blood vessels and heart tissue, and clinical studies such as in patients with heart attack or undergoing surgery. These allow us to understand the mechanisms of ischemia-reperfusion injury and how we might be able to intervene to optimise results from reperfusion treatments. These findings are relevant to both the heart and the brain.
The ongoing areas of research are related to clinical studies of remote conditioning in patients with heart attack, investigation of the role of adenosine in remote preconditioning pathways, and targetting the microcirculation after heart attack treatment to improve outcomes.
Coronary microvascular dysfunction in patients with stable coronary artery disease: The CE-MARC 2 coronary physiology sub-study.
Corcoran D. et al, (2018), Int j cardiol, 266, 7 - 14
Safety of the Deferral of Coronary Revascularization on the Basis of Instantaneous Wave-Free Ratio and Fractional Flow Reserve Measurements in Stable Coronary Artery Disease and Acute Coronary Syndromes.
Escaned J. et al, (2018), Jacc cardiovasc interv, 11, 1437 - 1449
Index of microcirculatory resistance-guided therapy with pressure-controlled intermittent coronary sinus occlusion improves coronary microvascular function and reduces infarct size in patients with ST-elevation myocardial infarction: the Oxford Acute Myocardial Infarction - Pressure-controlled Intermittent Coronary Sinus Occlusion study (OxAMI-PICSO study).
De Maria GL. et al, (2018), Eurointervention, 14, e352 - e359
What are the causes of a suboptimal FFR after coronary stent deployment? Insights from a consecutive series using OCT imaging.
Wolfrum M. et al, (2018), Eurointervention
Transverse partial stent ablation with rotational atherectomy for suboptimal culotte technique in left main stem bifurcation.
De Maria GL. et al, (2018), Catheter cardiovasc interv, 91, 1074 - 1078