Associate Professor of Cardiovascular Medicine
- Consultant Cardiologist
The focus of our work is on understanding ischemia-reperfusion injury and how this can be reduced particularly by remote preconditioning. In addition to understanding heart muscle responses, we are also interested in blood vessel injury, particularly the microcirculation.
We have developed a number of models to study ischemia-reperfusion injury in humans including ex-vivo and in-vivo models of blood vessels and heart tissue, and clinical studies such as in patients with heart attack or undergoing surgery. These allow us to understand the mechanisms of ischemia-reperfusion injury and how we might be able to intervene to optimise results from reperfusion treatments. These findings are relevant to both the heart and the brain.
The ongoing areas of research are related to clinical studies of remote conditioning in patients with heart attack, investigation of the role of adenosine in remote preconditioning pathways, and targetting the microcirculation after heart attack treatment to improve outcomes.
Index of Microcirculatory Resistance as a Tool to Characterize Microvascular Obstruction and to Predict Infarct Size Regression in Patients With STEMI Undergoing Primary PCI.
De Maria GL. et al, (2019), JACC Cardiovasc Imaging, 12, 837 - 848
UNEXPECTED INVERTED U-SHAPED RELATIONSHIP BETWEEN TROPONIN LEVEL AND MORTALITY EXPLAINED BY REVASCULARIZATION IN BOTH PATIENTS WITH AND WITHOUT ACUTE CORONARY SYNDROME (TROP-RISK STUDY)
Kaura A. et al, (2019), JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 73, 1086 - 1086
HSCRP PREDICTS MORTALITY BEYOND TROPONIN IN 102,337 PATIENTS WITH SUSPECTED ACUTE CORONARY SYNDROME IN THE UK NATIONAL INSTITUTE FOR HEALTH RESEARCH CRP-RISK STUDY
Kaura A. et al, (2019), JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 73, 10 - 10
CLINICAL IMPORTANCE OF TROPONIN LEVEL IN 3,121 PATIENTS PRESENTING WITH ATRIAL FIBRILLATION (AF-TROP STUDY)
Kaura A. et al, (2019), JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 73, 410 - 410
A PROPENSITY MATCHED ANALYSIS OF INVASIVE VERSUS CONSERVATIVE MANAGEMENT OF ELDERLY PATIENTS WITH NON-ST ELEVATION MYOCARDIAL INFARCTION (SENIOR-NSTEMI STUDY)
Kaura A. et al, (2019), JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 73, 1262 - 1262