Associate Professor of Cardiovascular Medicine
- Consultant Cardiologist
The focus of our work is on understanding ischemia-reperfusion injury and how this can be reduced particularly by remote preconditioning. In addition to understanding heart muscle responses, we are also interested in blood vessel injury, particularly the microcirculation.
We have developed a number of models to study ischemia-reperfusion injury in humans including ex-vivo and in-vivo models of blood vessels and heart tissue, and clinical studies such as in patients with heart attack or undergoing surgery. These allow us to understand the mechanisms of ischemia-reperfusion injury and how we might be able to intervene to optimise results from reperfusion treatments. These findings are relevant to both the heart and the brain.
The ongoing areas of research are related to clinical studies of remote conditioning in patients with heart attack, investigation of the role of adenosine in remote preconditioning pathways, and targetting the microcirculation after heart attack treatment to improve outcomes.
Acute Microvascular Impairment Post-Reperfused STEMI Is Reversible and Has Additional Clinical Predictive Value: A CMR OxAMI Study.
Borlotti A. et al, (2019), JACC Cardiovasc Imaging
What are the causes of a suboptimal FFR after coronary stent deployment? Insights from a consecutive series using OCT imaging.
Wolfrum M. et al, (2018), EuroIntervention, 14, e1324 - e1331
Viability testing to guide myocardial revascularisation in patients with heart failure
Cahill TJ. and Kharbanda RK., (2018), Indian Journal of Thoracic and Cardiovascular Surgery, 34, 206 - 212
Dynamic changes in injured myocardium, very early after acute myocardial infarction, quantified using T1 mapping cardiovascular magnetic resonance.
Alkhalil M. et al, (2018), J Cardiovasc Magn Reson, 20
Coronary microvascular dysfunction in patients with stable coronary artery disease: The CE-MARC 2 coronary physiology sub-study.
Corcoran D. et al, (2018), Int J Cardiol, 266, 7 - 14