Contact information
Colleges
Michael Desborough
BMedSci(Hons), MBChB, MRCP, FRCPath, DPhil
Consultant Haematologist & Honorary Senior Lecturer
The main focus of my research is assessing whether desmopressin could be used for treatment of thrombocytopenia or platelet dysfunction.
Platelets are a key part of clot formation. Patients with too few platelets, or platelets which are dysfunctional, are vulnerable to bleeding. One way to treat these patients is by transfusing platelets from a blood donor but this approach is often not effective. I am aiming to determine if desmopressin (a drug which increases platelet adhesion by stimulating release of Von Willebrand Factor) could be an effective adjuvant, or alternative treatment.
I am using a combination of methods to assess the value of desmopressin in this setting including meta-analysis of randomised controlled trials; laboratory assessment of thrombus formation under flow; and observational trials. I am leading two randomised placebo-controlled feasibility trials: desmopressin for prevention of bleeding in thrombocytopenia (DRIVE) and desmopressin for treatment of stroke due to haemorrhage (DASH).
Key publications
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Desmopressin use for minimising perioperative blood transfusion.
Journal article
Desborough MJ. et al, (2017), Cochrane Database Syst Rev, 7
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Desmopressin for treatment of platelet dysfunction and reversal of antiplatelet agents: a systematic review and meta-analysis of randomized controlled trials.
Journal article
Desborough MJR. et al, (2017), J Thromb Haemost, 15, 263 - 272
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Restrictive versus liberal blood transfusion for gastrointestinal bleeding: a systematic review and meta-analysis of randomised controlled trials.
Journal article
Odutayo A. et al, (2017), Lancet Gastroenterol Hepatol, 2, 354 - 360
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Effect of restrictive versus liberal red cell transfusion strategies on haemostasis: systematic review and meta-analysis.
Journal article
Desborough MJR. et al, (2017), Thromb Haemost, 117, 889 - 898
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Alternatives to allogeneic platelet transfusion.
Journal article
Desborough MJR. et al, (2016), Br J Haematol, 175, 381 - 392
Recent publications
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Updated hospital associated venous thromboembolism outcomes with 90-days follow-up after hospitalisation for severe COVID-19 in two UK critical care units.
Journal article
Doyle AJ. et al, (2020), Thromb Res, 196, 454 - 456
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Desmopressin for reversal of Antiplatelet drugs in Stroke due to Haemorrhage (DASH): protocol for a phase II double-blind randomised controlled feasibility trial.
Journal article
Desborough MJR. et al, (2020), BMJ Open, 10
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Real-World Evidence of Caplacizumab Use in the Management of Acute TTP.
Journal article
Dutt T. et al, (2020), Blood
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Bleeding of unknown cause and unclassified bleeding disorders; diagnosis, pathophysiology and management.
Journal article
Thomas W. et al, (2020), Haemophilia, 26, 946 - 957
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Image-proven thromboembolism in patients with severe COVID-19 in a tertiary critical care unit in the United Kingdom.
Journal article
Desborough MJR. et al, (2020), Thromb Res, 193, 1 - 4
ORCID
0000-0002-1951-5616