Contact information
Colleges
Michael Desborough
BMedSci(Hons), MBChB, MRCP, FRCPath, DPhil
Locum Consultant Haematologist & Honorary Senior Lecturer
I am a locum consultant haematologist and honorary senior lecturer at the Oxford Haemophilia and Thrombosis Centre. The main focus of my research is assessing whether desmopressin could be used for treatment of thrombocytopenia or platelet dysfunction.
Platelets are a key part of clot formation. Patients with too few platelets, or platelets which are dysfunctional, are vulnerable to bleeding. One way to treat these patients is by transfusing platelets from a blood donor but this approach is often not effective. I am aiming to determine if desmopressin (a drug which increases platelet adhesion by stimulating release of Von Willebrand Factor) could be an effective adjuvant, or alternative treatment.
I am using a combination of methods to assess the value of desmopressin in this setting including meta-analysis of randomised controlled trials; laboratory assessment of thrombus formation under flow; and observational trials. Two randomised placebo-controlled feasibility trials are in progress: desmopressin for prevention of bleeding in thrombocytopenia (DRIVE) and desmopressin for treatment of stroke due to haemorrhage (DASH).
Key publications
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Desmopressin use for minimising perioperative blood transfusion.
Journal article
Desborough MJ. et al, (2017), Cochrane Database Syst Rev, 7
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Desmopressin for treatment of platelet dysfunction and reversal of antiplatelet agents: a systematic review and meta-analysis of randomized controlled trials.
Journal article
Desborough MJR. et al, (2017), J Thromb Haemost, 15, 263 - 272
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Restrictive versus liberal blood transfusion for gastrointestinal bleeding: a systematic review and meta-analysis of randomised controlled trials.
Journal article
Odutayo A. et al, (2017), Lancet Gastroenterol Hepatol, 2, 354 - 360
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Effect of restrictive versus liberal red cell transfusion strategies on haemostasis: systematic review and meta-analysis.
Journal article
Desborough MJR. et al, (2017), Thromb Haemost, 117, 889 - 898
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Alternatives to allogeneic platelet transfusion.
Journal article
Desborough MJR. et al, (2016), Br J Haematol, 175, 381 - 392
Recent publications
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Desmopressin for reversal of Antiplatelet drugs in Stroke due to Haemorrhage (DASH): rationale and design of a phase II double blind randomised controlled trial
Conference paper
Desborough M. et al, (2019), BRITISH JOURNAL OF HAEMATOLOGY, 185, 139 - 139
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Coagulation status of critically ill patients with liver disease assessed using a novel thrombin generation analyser
Conference paper
Morrow GB. et al, (2019), BRITISH JOURNAL OF HAEMATOLOGY, 185, 137 - 137
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Can long acting factors go a long way; a real-life single centre retrospective study of Haemophilia B patients who have switched to extended half-life factor IX
Conference paper
Rampotas A. et al, (2019), BRITISH JOURNAL OF HAEMATOLOGY, 185, 138 - 139
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A HaemSTAR-led, UK-wide "Flash-Mob" audit of intravenous immunoglobulin use in immune thrombocytopenia
Conference paper
Nicolson PL. et al, (2019), BRITISH JOURNAL OF HAEMATOLOGY, 185, 9 - 10
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Transfusion of red blood cells stored for shorter versus longer duration for all conditions.
Journal article
Shah A. et al, (2018), Cochrane Database Syst Rev, 12
ORCID
0000-0002-1951-5616