Contact information
michael.desborough@linacre.ox.ac.uk
michael.desborough@ouh.nhs.uk
Department of Clinical Haematology, Churchill Hospital, Oxford, OX3 9DU
He/Him
Research groups
Colleges
Michael Desborough
BMedSci(Hons), MB ChB, FRCP, FRCPath, DPhil
Consultant Haematologist & Associate Professor of Haematology
The overarching aim of the research conducted by my group is to develop and trial new treatments for platelet disorders and finding alternatives to platelet transfusion.
- This includes trials of reversing antiplatelet drugs in intracerebral haemorrhage
- Optimising treatment of fetal and neonatal alloimmune thrombocytopenia (FNAIT)
- Clinical trials in transfusion medicine and immunohaematology [thrombotic thrombocytopenic purpura (TTP), immune thrombocytopenia (ITP), warm autoimmune haemolytic anaemia (wAIHA), cold agglutinin disease (CAD)]
- Developing the evidence base for platelet transfusion and alternatives to transfusion
Key publications
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Desmopressin for patients with spontaneous intracerebral haemorrhage taking antiplatelet drugs (DASH): a UK-based, phase 2, randomised, placebo-controlled, multicentre feasibility trial.
Journal article
Desborough MJR. et al, (2023), Lancet Neurol, 22, 557 - 567
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Restrictive versus liberal blood transfusion for gastrointestinal bleeding: a systematic review and meta-analysis of randomised controlled trials.
Journal article
Odutayo A. et al, (2017), Lancet Gastroenterol Hepatol, 2, 354 - 360
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Current practice and registration patterns among United Kingdom Haemophilia Centre Doctors' Organisation centers for patients with unclassified bleeding disorders.
Journal article
Thomas W. et al, (2021), J Thromb Haemost
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Drug-induced thrombotic thrombocytopenic purpura: A systematic review and review of European and North American pharmacovigilance data.
Conference paper
Schofield J. et al, (2022), Br J Haematol
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Real-World Evidence of Caplacizumab Use in the Management of Acute TTP.
Journal article
Dutt T. et al, (2020), Blood
Recent publications
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Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA.
Journal article
Murphy L. et al, (2025), Science, 389
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Carbon footprint of a sample of clinical trials for people with neurological disorders: cross-sectional analysis.
Journal article
Cranley D. et al, (2025), BMJ Open, 15
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Baseline serum ferritin predicts myocardial iron uptake following intravenous iron therapy - a hypothesis-generating study.
Journal article
Nunez J. et al, (2025), Eur J Heart Fail
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Blood transfusion strategies for major bleeding in trauma.
Journal article
Brunskill SJ. et al, (2025), Cochrane Database Syst Rev, 4
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Baseline ferritin predicts myocardial iron uptake following intravenous iron therapy- a hypothesis generating study
Preprint
Nunez J. et al, (2025)
ORCID
0000-0002-1951-5616