Contact information
Colleges
Michael Desborough
BMedSci(Hons), MBChB, MRCP, FRCPath, DPhil
Locum Consultant Haematologist & Honorary Senior Lecturer
I am a locum consultant haematologist and honorary senior lecturer at the Oxford Haemophilia and Thrombosis Centre. The main focus of my research is assessing whether desmopressin could be used for treatment of thrombocytopenia or platelet dysfunction.
Platelets are a key part of clot formation. Patients with too few platelets, or platelets which are dysfunctional, are vulnerable to bleeding. One way to treat these patients is by transfusing platelets from a blood donor but this approach is often not effective. I am aiming to determine if desmopressin (a drug which increases platelet adhesion by stimulating release of Von Willebrand Factor) could be an effective adjuvant, or alternative treatment.
I am using a combination of methods to assess the value of desmopressin in this setting including meta-analysis of randomised controlled trials; laboratory assessment of thrombus formation under flow; and observational trials. Two randomised placebo-controlled feasibility trials are in progress: desmopressin for prevention of bleeding in thrombocytopenia (DRIVE) and desmopressin for treatment of stroke due to haemorrhage (DASH).
Key publications
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Desmopressin use for minimising perioperative blood transfusion.
Journal article
Desborough MJ. et al, (2017), Cochrane Database Syst Rev, 7
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Desmopressin for treatment of platelet dysfunction and reversal of antiplatelet agents: a systematic review and meta-analysis of randomized controlled trials.
Journal article
Desborough MJR. et al, (2017), J Thromb Haemost, 15, 263 - 272
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Restrictive versus liberal blood transfusion for gastrointestinal bleeding: a systematic review and meta-analysis of randomised controlled trials.
Journal article
Odutayo A. et al, (2017), Lancet Gastroenterol Hepatol, 2, 354 - 360
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Effect of restrictive versus liberal red cell transfusion strategies on haemostasis: systematic review and meta-analysis.
Journal article
Desborough MJR. et al, (2017), Thromb Haemost, 117, 889 - 898
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Alternatives to allogeneic platelet transfusion.
Journal article
Desborough MJR. et al, (2016), Br J Haematol, 175, 381 - 392
Recent publications
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Transfusion of red blood cells stored for shorter versus longer duration for all conditions.
Journal article
Shah A. et al, (2018), Cochrane Database Syst Rev, 12
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Periprocedural antithrombotic management for lumbar puncture: Association of British Neurologists clinical guideline.
Journal article
Dodd KC. et al, (2018), Pract Neurol
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Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe hemorrhage.
Journal article
Desborough MJR. et al, (2018), J Thromb Haemost, 16, 1025 - 1027
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Clinical bleeding and thrombin generation in admissions to critical care with prolonged prothrombin time: an exploratory study.
Journal article
Stanworth SJ. et al, (2018), Transfusion
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HaemSTAR: A National Network of Trainee Haematologists Engaging in Non-Malignant Clinical Trials
Conference paper
Tucker D. et al, (2018), BRITISH JOURNAL OF HAEMATOLOGY, 181, 65 - 65
ORCID
0000-0002-1951-5616