Dr Mayooran Shanmuganathan

RESEARCH

My research focuses on cardiac magnetic resonance imaging (CMR) based biomarkers of myocardial injury.

I will try to establish if acute CMR scans, done before invasive coronary angiogram in patients with suspected acute coronary syndrome, can act as a safe gate keeper for the latter. i.e. can an acute CMR scan prevent unnecessary invasive procedures in patients with chest pain and signs of myocardial injury on blood test?  I will work with the group to establish if T1 mapping on CMR offers the possibility of a needle-free, non-contrast and fast CMR scans with an in-line analysis of pathology in patients with acute and chronic ischaemic heart disease. During my DPhil study, I will also assess the role of acute multi-parametric CMR scans in guiding individualised patient management (precision medicine), reducing healthcare provider costs and in predicting clinical outcomes.

I work closely with the research teams of my 3 supervisors: Professors Vanessa Ferreira, Keith Channon and Stefan Piechnik.  My work involves studying patients recruited in the Oxford Acute Myocardial Infarction (OXAMI) study, where I also perform research into finding new clinical biomarkers from blood samples and invasive coronary artery physiology taken in patients at the time of an acute myocardial infarction.

BACKGROUND

Clinical experience: I am a qualified clinician with dual accreditation in Cardiology and General Internal Medicine. I qualified with MBBS and BSc (1^st class Hons) from Imperial College London in 2008. I became a member of the Royal College of Physicians in London in 2011.  I finished my sub-speciality clinical training in 2018 in Advanced Heart Failure, Heart Transplantation and Mechanical Circulatory Devices at Royal Brompton and Harefield Hospital NHS Trust, where I work as locum consultant cardiologist and continue to collaborate on clinical and research projects.

Research experience: Wellcome Trust Fellowship, Harvard Medical School 2007. Academic Foundation Year Fellowship, Imperial College London 2008-2010. Clinical Research Fellow, NHLI, Imperial College London 2017-2018.