Dr Mayooran Shanmuganathan
BSc (Hons), MBBS, MRCP
Clinical Research Fellow / DPhil Student
My research focuses on cardiac magnetic resonance imaging (CMR) based biomarkers of myocardial injury.
Firstly I am trying to establish if acute CMR scans, done before patients with suspected acute coronary syndrome go for invasive coronary angiogram, can act as a safe gate keeper for the latter. i.e. can an acute CMR scan prevent unnecessary invasive procedures in patients with chest pain and signs of myocardial injury on blood test? Secondly, T1 mapping using CMR offers the possibility of a needle-free, non-contrast and fast CMR scans with an in-line analysis of pathology. During my DPhil study, I will assess the role of acute CMR scans in guiding individualised patient management (precision medicine), reducing healthcare provider costs and in predicting clinical outcomes.
I work closely with the research teams of my 3 supervisors: Professors Vanessa Ferreira, Keith Channon and Stefan Piechnik. My work involves studying patients recruited in the Oxford Acute Myocardial Infarction (OXAMI) study, where I also perform research into finding new clinical biomarkers from blood samples and invasive coronary artery physiology taken in patients at the time of an acute myocardial infarction.
Clinical experience: I am a qualified clinician with dual accreditation in Cardiology and General Internal Medicine. I qualified with MBBS and BSc (1st class Hons) from Imperial College London in 2008. I became a member of the Royal College of Physicians in London in 2011. I finished my sub-speciality clinical training in 2018 in Advanced Heart Failure, Heart Transplantation and Mechanical Circulatory Devices at Royal Brompton and Harefield Hospital NHS Trust, where I work as locum consultant cardiologist and continue to collaborate on clinical and research projects.
Research experience: Welcome Trust Fellowship, Harvard Medical School 2007. Academic Foundation Year Fellowship, Imperial College London 2008-2010. Clinical Research Fellow, NHLI, Imperial College London 2017-2018.
Outside of work, I am actively involved in multiple charitable projects and enjoy playing cricket and travelling the world with my young family.
ATGL Deficiency-Induced Triglyceride Deposit Cardiomyovasculopathy Requiring Heart Transplant: A 5-Year Follow-Up
Rajani P. et al, (2020), Jacc Case Reports, 2, 760 - 763
Angiography-derived index of microcirculatory resistance as a novel, pressure-wire-free tool to assess coronary microcirculation in ST elevation myocardial infarction.
De Maria GL. et al, (2020), Int J Cardiovasc Imaging
UTILITY OF CARDIAC MRI IN PREDICTION OF ACUTE RIGHT VENTRICULAR FAILURE AFTER LVAD
Moledina S. et al, (2020), Journal of the American College of Cardiology, 75
Complications of heart transplantation
SHANMUGANATHAN M. and Dar O., (2020), Cardiac Surgery A Complete Guide
Pressure-bounded coronary flow reserve to assess the extent of microvascular dysfunction in patients with ST-elevation acute myocardial infarction.
Scarsini R. et al, (2019), EuroIntervention
Role of adjuvant carotid ultrasound in women undergoing stress echocardiography for the assessment of suspected angina with no previous history of coronary artery disease
Gurunathan S. et al, (2019)
Developments in Heart Failure: Mechanical Unloading with LVADs, Exosomes, and MicroRNAs
SHANMUGANATHAN M. and Guymer S., (2019), Heart of the Matter Key concepts in cardiovascular science, 167 - 177
Development and preclinical testing of upscaled engineered heart tissue for use in translational studies
Jabbour R. et al, (2019), European Heart Journal, 40, 3273 - 3273
Spontaneous subdural haematoma in a patient with a total artificial heart on warfarin.
Moledina S. et al, (2019), BMJ Case Rep, 12
Longitudinal Exosomal and Tissue Expression of microRNA-208a and 208b in Acute and Chronic Rat Post-Myocardial Infarction Remodelling
Guymer SC. et al, (2018), 138, A15875 - A15875