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- Thakker Group: Academic Endocrine Unit Research Group
BSc (Hons); PhD
My current research focuses on understanding the mechanisms resulting in endocrine tumour formation and developing targeted therapies particularly for pancreatic, pituitary and parathyroid tumours (Thakker, Oxford). By identifying and understanding the underlying genetic defects, we aim to establish improved diagnostic tools and targeted therapies that can be translated into improved patient care. This has included characterizing models of hyperparathyroidism-jaw tumour syndrome and multiple endocrine neoplasia type 1 (MEN1), and use of a somatostatin analogue to treat pancreatic and pituitary tumours in in vivo models.
Prior to this I have studied the role of protein arginine methyltransferase 5 (PRMT5) in the growth of ovarian tumour cells (La Thangue, Oxford), and have a broad interest in the field of genetic therapies, particularly in regard to vector development for systemic administrations for the treatment of cancer which included developing targeted adenoviral vectors for the treatment of prostate cancer (Seymour, Oxford). I have also worked on the detection of the human papillomavirus type 16 E2 regulatory protein in cervical tissue (Maitland, York).
My PhD was performed at the University of Birmingham and involved the development of in-situ hybridisation for the cytogenetic analysis of Allium.
Molecular genetics of syndromic and non-syndromic forms of parathyroid carcinoma.
Cardoso L. et al, (2017), Hum Mutat
Mice deleted for cell division cycle 73 gene develop parathyroid and uterine tumours: model for the hyperparathyroidism-jaw tumour syndrome.
Walls GV. et al, (2017), Oncogene, 36, 4025 - 4036
Epigenetic pathway inhibitors represent potential drugs for treating pancreatic and bronchial neuroendocrine tumors.
Lines KE. et al, (2017), Oncogenesis, 6
A MEN1 pancreatic neuroendocrine tumour mouse model under temporal control.
Lines KE. et al, (2017), Endocr Connect, 6, 232 - 242
Genomic profiling reveals mutational landscape in parathyroid carcinomas.
Pandya C. et al, (2017), JCI Insight, 2