BSc (Hons), PhD
University Research Lecturer
- British Heart Foundation Intermediate Basic Science Research Fellow
Mark Crabtree is a British Heart Foundation Intermediate Basic Science Research Fellow and became a Group Leader and University Research Lecturer within the Division of Cardiovascular Medicine in 2015. His research group focuses on understanding the mechanisms of nitric oxide and redox signalling in molecular models of cardiovascular disease.
He began his postdoctoral research with Professor Keith Channon in 2006 and he held an internal University of Oxford British Heart Foundation Centre of Research Excellence Transition Fellowship (2012-2015). Mark did a collaborative PhD with the University of Surrey and Weill Medical College of Cornell University in New York City, having completed his BSc at the University of Surrey in 2001.
His research interests focus on metabolomic and proteomic approaches to understand the impact of redox alterations in molecular and mouse models of cardiovascular homeostasis and disease.
Tetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation.
Bailey J. et al, (2018), Sci rep, 8
Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression.
Douglas G. et al, (2018), Cardiovasc res, 114, 1385 - 1399
Effects Of Endothelin-1 On Intracellular Tetrahydrobiopterin Levels In Vascular Tissue.
Cerrato R. et al, (2018), Scand cardiovasc j, 52, 163 - 169
A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice.
Chuaiphichai S. et al, (2017), Br j pharmacol, 174, 657 - 671
A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance.
Bailey J. et al, (2017), Free radic biol med, 104, 214 - 225