Mariana Pereira Pinho
Postdoctoral Researcher
Tumor-specific T cell response
My research focuses on the analysis of T cells capable of recognizing and reacting to tumor antigens. Specifically, I am interested in evaluating the specificity and function of tumor-reactive T cells, especially in the context of breast cancer. Beyond characterizing their specificity and function, I investigate how these cells respond to different immunotherapies and how these insights can be harnessed to design more effective treatments. Ultimately, my research aims to expand the potential of immunotherapy by uncovering the rules that govern successful anti-tumor T cell responses.
Key publications
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Tumor-specific CD8 T cell characterization in HR+ breast cancer reveals an impaired antitumoral response in patients with lymph node metastasis.
Journal article
Pinho MP. et al, (2025), Cell Rep Med
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A blood atlas of COVID-19 defines hallmarks of disease severity and specificity.
Journal article
COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium. Electronic address: julian.knight@well.ox.ac.uk None. and COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium None., (2022), Cell, 185, 916 - 938.e58
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Frequency determination of breast tumor-reactive CD4 and CD8 T cells in humans: unveiling the antitumor immune response.
Journal article
Pinho MP. et al, (2019), Oncoimmunology, 8
Recent publications
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Tumor-specific CD8 T cell characterization in HR+ breast cancer reveals an impaired antitumoral response in patients with lymph node metastasis.
Journal article
Pinho MP. et al, (2025), Cell Rep Med
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Quality of Life Analysis in Patients Submitted to Dendritic Cell Vaccination for High Grade Gliomas: Update Report on a Phase II DC Trial
Preprint
Lepski GA. et al, (2025)
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Profiling of Tumor-Infiltrating Immune Cells and Their Impact on Survival in Glioblastoma Patients Undergoing Immunotherapy with Dendritic Cells
Journal article
Peres N. et al, (2024), International Journal of Molecular Sciences, 25, 5275 - 5275
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A robust deep learning workflow to predict CD8 + T-cell epitopes.
Journal article
Lee CH. et al, (2023), Genome Med, 15
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Adjuvant Vaccination with Allogenic Dendritic Cells Significantly Prolongs Overall Survival in High-Grade Gliomas: Results of a Phase II Trial
Journal article
Lepski G. et al, (2023), Cancers, 15, 1239 - 1239