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Lea Nussbaum


DPhil Student

I am a DPhil student on the Wellcome Trust “Infection, Immunology and Translational Medicine” programme working under the supervision of Graham Ogg.

My research focuses on CD1a-restricted regulatory T cell responses in psoriasis. Increasing evidence supports a role for regulatory T cells (Tregs) in control of psoriasis. The non-classical antigen presenting molecule CD1a is predominantly expressed on antigen presenting cells (APCs) in the skin. Through CD1a, skin APCs can present lipid antigens to T cells and modulate the immune response. Whereas CD1a-reactive effector T cells have been shown to contribute to disease pathogenesis in inflammatory skin diseases such as psoriasis, the impact of CD1a on Treg regulation is still elusive. We therefore aim to determine whether CD1a-reactive Treg cells can modulate immune responses in the setting of psoriasis. I am further investigating the CD1a-mediated impact of skin-related bacteria which might regulate the skin immune system, e.g. by induction and activation of Tregs.