- Multiple Sclerosis Basic and Translational Research Group Research Group
Professor of Neuroimmunology
Multiple sclerosis (MS) is a common chronic inflammatory and degenerative disease of the central nervous system. Inherited susceptibility to MS is primarily associated with certain MHC genes. In addition, unknown environmental factors also seem to play a role in the disease. Our group is seeking to understand the molecular basis for the MHC association in MS and how MHC genes interact with environmental factors such as viruses. We are also investigating how the MHC associated inflammation leads to neurodegeneration, which is responsible for the long-term disability in MS patients. We are taking a multidisciplinary approach which is possible through a strong network of local and international collaborators. There is a strong focus on translational medicine and both clinicians and non-clinicians are working in the group.
Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.
Ooi JD. et al, (2017), Nature, 545, 243 - 247
Severe B-cell-mediated CNS disease secondary to alemtuzumab therapy.
Haghikia A. et al, (2017), Lancet Neurol, 16, 104 - 106
Neuroinflammation - using big data to inform clinical practice.
Dendrou CA. et al, (2016), Nat Rev Neurol, 12, 685 - 698
Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity.
Dendrou CA. et al, (2016), Sci Transl Med, 8
Antigen Targeting to Human HLA Class II Molecules Increases Efficacy of DNA Vaccination.
Grodeland G. et al, (2016), J Immunol, 197, 3575 - 3585