DPHIL PROJECTS AVAILABLE
Associate Professor of Metabolic Imaging
- Sir Henry Dale Fellow of the Wellcome Trust
Investigation of energy metabolism in human tissues using ultra high field magnetic resonance spectroscopy.
My research focuses on magnetic resonance (MR) metabolic imaging. This involves quantification of energy metabolites and metabolic reaction rates using MR spectroscopy (MRS), to non-invasively detect metabolic impairments and to monitor therapy outcome. My work focuses on method development for the assessment of energy metabolism of human heart, liver and skeletal muscle in disease. This is crucial to understand the impact of systemic and cardiovascular diseases on these systems. A lot of my work examines interventions of increased physical activity to improve oxidative metabolism and exercise tolerance of elderly people and also to manage individual weight in obesity and diabetes.
I mainly use our ultra-high field (7T) MR system, as it provides exceptional signal-to-noise ratio (SNR), in particular for my phosphorus (31P)-MRS experiments. This improvement in SNR allows me to develop methods to acquire high quality spatially resolved data with high temporal resolution. In particular, I have developed the first clinically feasible technique worldwide that allows assessment of stimulated oxidative energy production rate, in only one exercise repetition. As nothing comes for free, 7T brings several challenges, eg field inhomogeneities. Therefore I also develop techniques to overcome these challenges, eg interleaved excitation with narrow-banded, field insensitive excitation pulse for cardiac energetics quantification. I collaborate with several research groups in Oxford interested in non-invasive oxidative metabolism measurements. I am also a former member of the MRS group at the Medical University of Vienna, and thus, have strong ties to research groups in Central Europe, ie Austria, Slovakia and Czech Republic, interested in MRS method development and exercise interventions.
Increased cardiac Pi/PCr in the diabetic heart observed using phosphorus magnetic resonance spectroscopy at 7T
Valkovič L. et al, (2022), PLOS ONE, 17, e0269957 - e0269957
Evaluation of Acute Supplementation With the Ketone Ester (R)-3-Hydroxybutyl-(R)-3-Hydroxybutyrate (deltaG) in Healthy Volunteers by Cardiac and Skeletal Muscle 31P Magnetic Resonance Spectroscopy
Cameron D. et al, (2022), Frontiers in Physiology, 13
2½-minute 3D 7T 31P-MRSI of the human heart using concentric rings (CRT)
Clarke WT. et al, (2021)
Intentional Weight Loss as a Novel Treatment for Heart Failure with Preserved Ejection Fraction
Hundertmark MJ. et al, (2021), CIRCULATION, 144
Myocardial Energetic Impairment is the Basis for Reduced Cardiac Reserve and Exercise-Induced Pulmonary Congestion in Heart Failure With Preserved Ejection Fraction: Insights From Novel Cardiopulmonary Magnetic Resonance Imaging
Burrage MK. et al, (2021), CIRCULATION, 144