Associate Professor of Metabolic Imaging
- Sir Henry Dale Fellow of the Wellcome Trust
Investigation of energy metabolism in human tissues using ultra high field magnetic resonance spectroscopy.
My research focuses on magnetic resonance (MR) metabolic imaging. This involves quantification of energy metabolites and metabolic reaction rates using MR spectroscopy (MRS), to non-invasively detect metabolic impairments and to monitor therapy outcome. My work focuses on method development for the assessment of energy metabolism of human heart, liver and skeletal muscle in disease. This is crucial to understand the impact of systemic and cardiovascular diseases on these systems. A lot of my work examines interventions of increased physical activity to improve oxidative metabolism and exercise tolerance of elderly people and also to manage individual weight in obesity and diabetes.
I mainly use our ultra-high field (7T) MR system, as it provides exceptional signal-to-noise ratio (SNR), in particular for my phosphorus (31P)-MRS experiments. This improvement in SNR allows me to develop methods to acquire high quality spatially resolved data with high temporal resolution. In particular, I have developed the first clinically feasible technique worldwide that allows assessment of stimulated oxidative energy production rate, in only one exercise repetition. As nothing comes for free, 7T brings several challenges, eg field inhomogeneities. Therefore I also develop techniques to overcome these challenges, eg interleaved excitation with narrow-banded, field insensitive excitation pulse for cardiac energetics quantification. I collaborate with several research groups in Oxford interested in non-invasive oxidative metabolism measurements. I am also a former member of the MRS group at the Medical University of Vienna, and thus, have strong ties to research groups in Central Europe, ie Austria, Slovakia and Czech Republic, interested in MRS method development and exercise interventions.
Rapid 3D absolute B
mapping using a sandwiched train presaturated TurboFLASH sequence at 7 T for the brain and heart
Kent JL. et al, (2022), Magnetic Resonance in Medicine
Maternal Cardiac Changes in Women With Obesity and Gestational Diabetes Mellitus.
Thirunavukarasu S. et al, (2022), Diabetes Care
2½-minute 3D 7T 31 P-MRSI of the human heart using concentric rings (CRT).
Clarke W. et al, (2022), NMR Biomed
Letter regarding the article "Cardiac Energetics in Patients with Chronic Heart Failure and Iron Deficiency: An in-vivo 31P Magnetic Resonance Study".
Burrage MK. et al, (2022), Eur J Heart Fail
MEASURING PCR/ATP AS A MARKER OF MYOCARDIAL ENERGETICS ACROSS THE SPECTRUM OF METABOLIC CARDIAC DISEASE
Henry JA. et al, (2022), HEART, 108, A109 - A110