Contact information
Kamayani Singh
MSc (Applied Biochemistry); PhD
Postdoctoral Researcher
I completed my masters in Biochemistry from VBS Purvanchal University, India. Subsequently, I moved to Germany, for my PhD. During my PhD, I worked on psoriasis mouse model, and analysed the Treg-Th17 plasticity in CD18 hypo mouse model. Currently, I am working with Prof Shoumo Bhattacharya on screening and characterization of novel chemokine binding proteins from tick saliva (evasins), using Yeast surface display techniques. In order to further characterize these novel screened evasins as a therapeutic targets in several cardiovascular diseases like myocarditis and myocardial infarction, I am also involved in the development of experimental autoimmune myocarditis (EAM) and myocardial infarction (in collaboration) mouse models, and investigate therapeutic role of these evasins in these mouse models.
Recent publications
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Transcriptomic Analysis of Inflammatory Cardiomyopathy Identifies Molecular Signatures of Disease and Informs in silico Prediction of a Network-Based Rationale for Therapy.
Journal article
Singh K. et al, (2021), Front Immunol, 12
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A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins.
Journal article
Lee AW. et al, (2019), J Biol Chem, 294, 11199 - 11212
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Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets.
Journal article
Alenazi Y. et al, (2018), Sci Rep, 8
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The N-terminal domain of a tick evasin is critical for chemokine binding and neutralization and confers specific binding activity to other evasins.
Journal article
Eaton JRO. et al, (2018), J Biol Chem, 293, 6134 - 6146
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Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.
Journal article
Singh K. et al, (2017), Sci Rep, 7