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Colleges
DPhil projects available
AKR1C1 as a therapeutic target in non-alcholoic fatty liver diease and hepatocellular carcinoma
Jeremy Tomlinson
MB BCh, PhD, FRCP
Professor of Metabolic Endocrinology
My work tries to better understand and treat metabolic diseases, in particular, non-alcholic fatty liver disease (NAFLD). Our work has focused on the role of steroid hormones and their metabolism in the development, assessment and treatment of metabolic diseases including NAFLD, obesity and type 2 diabetes. Our previous work has shown that altering steroid hormone metabolism can have a potent impact on the function of both liver and adipose tissue to store fat. Our future work will use steroid biomarkers not only to stage disease severity, but to predict progression. In addition, by altering tissue specific-metabolism, we hope to limit the side effects of prescribed steroids.
Key publications
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Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man.
Journal article
Hazlehurst JM. et al, (2016), J Clin Endocrinol Metab, 101, 103 - 113
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Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis.
Journal article
Armstrong MJ. et al, (2016), J Hepatol, 64, 399 - 408
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5α-Reductase Type 2 Regulates Glucocorticoid Action and Metabolic Phenotype in Human Hepatocytes.
Journal article
Nasiri M. et al, (2015), Endocrinology, 156, 2863 - 2871
Recent publications
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Association of weight changes with changes in histological features and blood markers in non-alcoholic steatohepatitis
Journal article
KOUTOUKIDIS D. et al, (2021), Clinical Gastroenterology and Hepatology
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International practice of corticosteroid replacement therapy in congenital adrenal hyperplasia: data from the I-CAH registry.
Journal article
Bacila I. et al, (2021), Eur J Endocrinol, 184, 553 - 563
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Differential activity and expression of human 5β-reductase (AKR1D1) splice variants.
Journal article
Appanna N. et al, (2021), J Mol Endocrinol, 66, 181 - 194
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The role of 5-reduction in physiology and metabolic disease: evidence from cellular, pre-clinical and human studies.
Journal article
Nikolaou N. et al, (2021), J Steroid Biochem Mol Biol, 207
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Relative Adipose Tissue Failure in Alström Syndrome Drives Obesity-Induced Insulin Resistance.
Journal article
Geberhiwot T. et al, (2021), Diabetes, 70, 364 - 376