Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.
Skip to main content

Graham Davies

Head of Chemokine Technology Development

My research is focussed on discovering and developing new drugs that can be used to treat heart diseases where inflammation plays a major role. Through employing yeast surface display a number of small proteins called evasins have been identified from tick saliva. These evasins have a unique “one-to-many” mechanism of action, i.e. they bind multiple chemokines, and potently block inflammation. The “one-to-many” action of the evasins overcomes the robustness of the chemokine system, which is unaffected by traditional anti-chemokine drugs that work on a “one-to-one” basis. Chemokines are produced by the body in response to injury, and bring in white blood cells that cause further damage through a process known as migration. I have developed a number of techniques utilising high throughput flow cytometry to functionally validate the evasins. These include fluorescent ligand binding/competition assays and a raft of human and mouse primary cell migration assays. My current work is focussed on the development of the delivery of the evasins to site of inflammation and the development of a bacterial cell surface display technique to enable identification of critical residues in the evasin:chemokine interaction.