Contact information
Colleges
Collaborators
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Adam Mead
Professor of Haematology
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Supat Thongjuea
Oxford-BMS Research Fellow
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Claus Nerlov
Professor of Stem Cell Biology
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Guanlin Wang
Postdoctoral researcher
Bethan Psaila
MA; MBBS; MRCP; FRCPath; PhD
Associate Professor of Haematology
- Cancer Research UK Advanced Clinician Scientist
Using single-cell approaches to study normal and malignant megakaryocyte development and myeloproliferative neoplasms
I study megakaryocytes - large, rare cells found in the bone marrow that release blood platelets into the circulation and also produce many growth factors and other proteins that regulate blood cell development and the bone marrow microenvironment. My group applies state-of-the-art single-cell approaches to clarify the cellular pathways by which megakaryocytes arise from haematopoietic stem cells. This is important as in certain malignancies, such as erythro-megakaryocytic leukaemias and myeloproliferative neoplasms, megakaryocytes develop abnormally and contribute to key pathological features of the disease, including the harmful scarring that destroys the bone marrow.
I trained at Clare College, Cambridge, Imperial College London/The Hammersmith Hospital, Cornell, New York, and the National Institutes of Health, Bethesda USA and am currently a Cancer Research UK Advanced Clinician Scientist and Honorary Consultant in Haematology, Oxford University Hospitals NHS Trust. I am also a Senior Fellow of New College, Oxford.
Key publications
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Journal article
Khan AO. et al, (2022), Cancer Discov
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Journal article
Psaila B. et al, (2020), Mol Cell, 78, 477 - 492.e8
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Journal article
Psaila B. et al, (2016), Genome Biol, 17
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Journal article
Sousos N. et al, (2022), Nat Med, 28, 1207 - 1211
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Journal article
Roy A. et al, (2021), Cell Rep, 36
Recent publications
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Journal article
Rampotas A. et al, (2023), Blood
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Journal article
McLornan DP. et al, (2023), Br J Haematol
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Journal article
Rodriguez-Meira A. et al, (2023), Nat Genet
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Journal article
Ryou H. et al, (2023), Leukemia
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CHROMOTHRIPSIS AND LEUKEMIC TRANSFORMATION IN MPN
Conference paper
Brierley C. et al, (2023), EXPERIMENTAL HEMATOLOGY, 124, S65 - S65
ORCID
0000-0001-8198-9663