MA; MBBS; MRCP; FRCPath; PhD
Wellcome Trust Clinical Research Fellow
Using single-cell approaches to study normal and malignant megakaryocyte development
I study megakaryocytes - large, rare cells found in the bone marrow that release blood platelets into the circulation and also produce many growth factors and other proteins that regulate blood cell development and the bone marrow microenvironment. Recently, I have focused on using single-cell approaches to clarify the cellular pathways by which megakaryocytes arise from haematopoietic stem cells. This is important as in certain malignancies, such as erythro-megakaryocytic leukaemias and myeloproliferative neoplasms, megakaryocytes develop abnormally and contribute to key pathological features of the disease. Since 2015 I have been collaborating with Dr David Bodine at the National Human Genome Research Institute, National Institutes of Health, USA, where I have been working on a visiting postdoctoral fellowship. Currently I am studying how megakaryocytes develop abnormally in a rare but fatal disease called Myelofibrosis, and how they contribute to the harmful scarring that destroys the bone marrow.
Single-cell approaches reveal novel cellular pathways for megakaryocyte and erythroid differentiation.
Psaila B. and Mead AJ., (2019), Blood, 133, 1427 - 1435
Unravelling Intratumoral Heterogeneity through High-Sensitivity Single-Cell Mutational Analysis and Parallel RNA Sequencing.
Rodriguez-Meira A. et al, (2019), Mol Cell, 73, 1292 - 1305.e8
Whole genome sequencing for the investigation of rare anaemias: Challenges and real-world outcomes
Brierley C. et al, (2019), BRITISH JOURNAL OF HAEMATOLOGY, 185, 115 - 116
A Single-Cell Approach to Unraveling Abnormal Megakaryocyte Differentiation and Function in Myelofibrosis
Psaila B. et al, (2017), BLOOD, 130
Eltrombopag: a powerful chelator of cellular or extracellular iron(III) alone or combined with a second chelator.
Vlachodimitropoulou E. et al, (2017), Blood, 130, 1923 - 1933