MA; MBBS; MRCP; FRCPath; PhD
Wellcome Trust Clinical Research Fellow
Using single-cell approaches to study normal and malignant megakaryocyte development
I study megakaryocytes - large, rare cells found in the bone marrow that release blood platelets into the circulation and also produce many growth factors and other proteins that regulate blood cell development and the bone marrow microenvironment. Recently, I have focused on using single-cell approaches to clarify the cellular pathways by which megakaryocytes arise from haematopoietic stem cells. This is important as in certain malignancies, such as erythro-megakaryocytic leukaemias and myeloproliferative neoplasms, megakaryocytes develop abnormally and contribute to key pathological features of the disease. Since 2015 I have been collaborating with Dr David Bodine at the National Human Genome Research Institute, National Institutes of Health, USA, where I have been working on a visiting postdoctoral fellowship. Currently I am studying how megakaryocytes develop abnormally in a rare but fatal disease called Myelofibrosis, and how they contribute to the harmful scarring that destroys the bone marrow.
Epigenetic and Single Cell Analyses Reveal Dual Fate Decision Points in Pre-Primed Hematopoietic Stem Cells during Erythro-Megakaryopoiesis
Heuston EF. et al, (2017), BLOOD, 130
Pre-metastatic niches: organ-specific homes for metastases.
Peinado H. et al, (2017), Nat Rev Cancer, 17, 302 - 317
Tense your megas! Structural rigidity is key.
Psaila B., (2016), Blood, 128, 1997 - 1999
Single-cell profiling of human megakaryocyte-erythroid progenitors identifies distinct megakaryocyte and erythroid differentiation pathways.
Psaila B. et al, (2016), Genome Biol, 17
PROSPECTIVE ISOLATION OF NOVEL POPULATIONS OF MEGAKARYOCYTE-AND ERYTHROID-PRIMED MEGAKARYOCYTE-ERYTHROID PROGENITORS DEMONSTRATES MEGAKARYOCYTE-BIASED LINEAGE COMMITMENT IN PRIMARY MYELOFIBROSIS
Psaila B. et al, (2015), HAEMATOLOGICA, 100, 97 - 97