Research groups
Websites
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MRC Molecular Haematology Unit
Research Unit
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MRC Weatherall Institute of Molecular Medicine
Research Institute
Research Projects Available
Paresh Vyas
MRCP FRCP FRCPath
Professor of Haematology
- Consultant Physician
Normal and Leukaemic stem/progenitor cell biology
Our aim is to characterise the heterogeneous populations of leukaemia propagating cells in adult and childhood Acute Myeloid Leukaemia (AML) at functional, genetic, epigenetic and molecular levels, eventually at a single cell level, to improve our basic understanding of leukaemia initiation and propagation. The ultimate aim is to translate this knowledge to improve survival rates in patients.
Biography
Paresh Vyas is Professor of Haematology at the University of Oxford. He studied medicine at Cambridge then Oxford. After completing his medical and haematology training in London, he did his PhD with Professor Doug Higgs and Professor Sir David Weatherall at the MRC Molecular Haematology Unit, Oxford. A three-year post-doctoral fellowship with Professor Stuart Orkin at Harvard University followed. He is a research-active Consultant Haematologist with a clinical practice in myeloid disorders: myelodysplastic syndrome, MDS, acute myeloid leukaemia, AML, and myeloproliferative disorders, MPD, as well as allogeneic stem cell transplant. His research in the MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, focuses on molecular and cellular biology of AML and MDS with specific interest in purification and therapeutic targeting of myeloid stem cells. He studies single cell biology in normal and leukaemic haemopoiesis. He is on the UK AML and MDS clinical trial groups.
Key publications
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Rapid clonal selection within early hematopoietic cell compartments presages outcome to ivosidenib combination therapy
Preprint
Turkalj S. et al, (2024)
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Hematopoietic stem cell heterogeneity and age-associated platelet bias are evolutionarily conserved.
Journal article
Aksöz M. et al, (2024), Sci Immunol, 9
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Risk Stratification in Older Intensively Treated Patients With AML.
Journal article
Versluis J. et al, (2024), J Clin Oncol, 42, 4084 - 4094
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Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging.
Journal article
Jakobsen NA. et al, (2024), Cell Stem Cell, 31, 1127 - 1144.e17
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Clinical significance of preleukemic somatic GATA1 mutations in children with Down syndrome.
Journal article
Elliott N. et al, (2025), Blood
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GTAC enables parallel genotyping of multiple genomic loci with chromatin accessibility profiling in single cells.
Journal article
Turkalj S. et al, (2023), Cell Stem Cell, 30, 722 - 740.e11
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C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor.
Journal article
Di Genua C. et al, (2020), Cancer Cell, 37, 690 - 704.e8
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Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.
Journal article
Labuhn M. et al, (2019), Cancer Cell, 36, 123 - 138.e10
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Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib.
Journal article
Quek L. et al, (2018), Nat Med, 24, 1167 - 1177
