MRC Molecular Haematology Unit
We aim to understand how mature blood cells are normally made from stem cells and how this is perturbed in common blood disorders. Ultimately, our purpose is to improve the management of patients with inherited and acquired blood diseases.
Outcome of Azacitidine Therapy in Acute Myeloid Leukemia is not Improved by Concurrent Vorinostat Therapy but is Predicted by a Diagnostic Molecular Signature.
Craddock C. et al, (2017), Clin Cancer Res
Amatangelo MD. et al, (2017), Blood, 130, 732 - 741
Stein EM. et al, (2017), Blood, 130, 722 - 731
Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes.
Unnikrishnan A. et al, (2017), Cell Rep, 20, 572 - 585
Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation.
Mead AJ. et al, (2017), J Exp Med, 214, 2005 - 2021