Lewis Group: Spatial Cardiology

We are an interdisciplinary team exploiting the potential of imaging across spatial scales to understand and treat human heart disease. Our research spans from the molecular level within individual cells to comprehensive whole-heart analysis, creating a unique perspective on cardiovascular health and disease.

We develop and apply advanced imaging techniques across these various spatial scales, from subcellular to whole-heart, to better understand cardiovascular disease mechanisms, identify new therapeutic targets, and enhance early detection of treatment effects in experimental medicine trials. Our approach bridges the gap between basic science and clinical application by integrating human cells, tissue samples, and non-invasive imaging of research and trial participants and patients. Through this comprehensive methodology, we aim to maximise the translational potential and mechanistic insights of our work.

Our current projects focus on metabolic and immunological pathways in heart failure, exploiting state-of-the-art spatial profiling techniques that allow us to map disease processes with unprecedented detail and precision. We believe that understanding how these pathways interact across different scales—from subcellular compartments to organ-level function—is key to developing more effective treatments.

We collaborate with a broad network of local, national, and international partners across academia and industry, fostering innovation through diverse perspectives and expertise. We welcome applicants with interdisciplinary expertise and are always excited to discuss how your background might contribute to our mission. Please reach out to discuss current opportunities with us.