Contact information
Colleges
Josephine Watkins
DPhil Student
I am a first-year DPhil student at Brasenose College, University of Oxford, co-supervised by Professors Christopher Toepfer and Andrew Lewis as part of the NIH OxCam Scholars Program. My research focuses on exploring genetic modifiers of hypertrophic cardiomyopathy (HCM) using advanced 3D cardiac organoid models derived from induced pluripotent stem cell–cardiomyocytes (iPSC-CMs). Through disease modelling and mechanistic investigation, I aim to better understand how genetic variation influences HCM phenotype and progression.
I graduated from Columbia University in May 2025 with a BS in Biomedical Engineering. Under the mentorship of Dr. Gordana Vunjak-Novakovic, I developed a strong interest in cardiovascular research. My undergraduate work included utilizing matured engineered heart tissues to model cardiac fibroblasts contribution to dilated cardiomyopathy.
Recent publications
The BAG3-HSP70-CHIP axis controls the degradation of TGFBR2 in cardiac fibroblasts
Journal article
Morsink MAJ. et al, (2025), Journal of Molecular and Cellular Cardiology, 205, 13 - 23
Cardiac fibroblast BAG3 regulates TGFBR2 signaling and fibrosis in dilated cardiomyopathy
Journal article
Wang BZ. et al, (2025), Journal of Clinical Investigation, 135
patient-specific engineered tissue model of BAG3-mediated cardiomyopathy
Journal article
Morsink MAJ. et al, (2025), Journal of Tissue Engineering, 16
Mechanism Of Bag3's Degradation Of Tgfbr2 In Cardiac Fibroblasts
Journal article
Morsink M. et al, (2023), CIRCULATION RESEARCH, 133
