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Drug repurposing screen identifies novel anti-inflammatory activity of sunitinib in macrophages.

Journal article

Chaffey LE. et al, (2024), Eur J Pharmacol

OxPhos in adipose tissue macrophages regulated by BTK enhances their M2-like phenotype and confers a systemic immunometabolic benefit in obesity

Preprint

Purvis G. et al, (2023)

A Human CD68 Promoter-Driven Inducible Cre-Recombinase Mouse Line Allows Specific Targeting of Tissue Resident Macrophages.

Journal article

Rumianek AN. et al, (2022), Front Immunol, 13

Impact of metabolic disorders on the structural, functional, and immunological integrity of the blood-brain barrier: Therapeutic avenues.

Journal article

Sheikh MH. et al, (2022), FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 36

Bruton's tyrosine kinase (BTK) regulates myeloid cell recruitment during acute inflammation.

Journal article

Purvis GSD. et al, (2021), Br J Pharmacol

A novel hCD68 CreERT(2) mouse strain for macrophage targeting in vivo

Conference paper

Rumianek A. et al, (2021), BRITISH JOURNAL OF PHARMACOLOGY, 178, 4949 - 4949

Novel anti-inflammatory activity of sunitinib malate identified in a macrophage drug-repurposing screen of FDA-approved medicines

Conference paper

Chaffey L. et al, (2021), BRITISH JOURNAL OF PHARMACOLOGY, 178, 4938 - 4939

Ly6Chi monocytes are metabolically reprogrammed in the blood during inflammatory stimulation allowing for macrophage lineage commitment

Preprint

Purvis GSD. et al, (2021)

A Synthetic Peptide Designed to Neutralize Lipopolysaccharides Attenuates Metaflammation and Diet-Induced Metabolic Derangements in Mice.

Journal article

Mohammad S. et al, (2021), Front Immunol, 12

X-LINKED IMMUNE DEFECT MICE ARE PROTECTED AGAINST SEPSIS-INDUCED CARDIAC DYSFUNCTION

Conference paper

O'Riordan C. et al, (2020), SHOCK, 53, 97 - 97

Inhibition of Bruton’s tyrosine kinase reduces NF-kB and NLRP3 inflammasome activity preventing insulin resistance and microvascular disease

Preprint

Purvis G. et al, (2019)

Inhibition of NF-kappa B Pathway with IKK-16 or Linagliptin Attenuates the Cardiac Dysfunction Associated with Polymicrobial Sepsis in Mice with Preexisting Type 2 Diabetes Mellitus (T2DM)

Conference paper

Al Zoubi S. et al, (2018), DIABETES, 67

Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes.

Journal article

Purvis GSD. et al, (2018), Diabetologia, 61, 482 - 495

Endogenous Annexin-A1 is a Protective Determinant in HFD-induced Insulin Resistance and Diabetic Nephropathy

Conference paper

Purvis GSD. et al, (2017), FASEB JOURNAL, 31

Endogenous annexin-A1 is a protective determinant in high-fat diet (HFD)-induced insulin resistance and diabetic nephropathy

Conference paper

Purvis GSD. et al, (2017), DIABETIC MEDICINE, 34, 26 - 26

Role of annexin-A1 on blood-brain barrier functionality

Conference paper

Purvis GSD. et al, (2017), DIABETIC MEDICINE, 34, 64 - 64

I kappa B KINASE INHIBITOR ATTENUATES SEPSIS-INDUCED CARDIAC DYSFUNCTION IN MICE WITH CKD

Conference paper

Chen J. et al, (2016), SHOCK, 46, 29 - 30