Publications — Radcliffe Department of Medicine

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A histone deacetylase 3 and mitochondrial complex I axis regulates toxic formaldehyde production.

Wit N. et al, (2023), Sci Adv, 9

Truncated FGFR2 is a clinically actionable oncogene in multiple cancers.

Zingg D. et al, (2022), Nature, 608, 609 - 617

Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps.

Paes Dias M. et al, (2021), Molecular cell, 81, 4692 - 4708.e9

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.

Gogola E. et al, (2019), Cancer Cell, 35, 950 - 952

Resistance to PARP Inhibitors: Lessons from Preclinical Models of BRCA-Associated Cancer

Gogola E. et al, (2019), Annual Review of Cancer Biology, 3, 235 - 254

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.

Gogola E. et al, (2018), Cancer Cell, 33, 1078 - 1093.e12

The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells.

Barazas M. et al, (2018), Cell Rep, 23, 2107 - 2118

Multifaceted Impact of MicroRNA 493-5p on Genome-Stabilizing Pathways Induces Platinum and PARP Inhibitor Resistance in BRCA2-Mutated Carcinomas

Meghani K. et al, (2018), Cell Reports, 23, 100 - 111

BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance

Duarte AA. et al, (2018), Nature Methods, 15, 134 - 140

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

Sachs N. et al, (2018), Cell, 172, 373 - 386.e10

EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation

Rondinelli B. et al, (2017), Nature Cell Biology, 19, 1371 - 1378

Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells.

Schoonen PM. et al, (2017), Nat Commun, 8

TRIM28 Is an Epigenetic Barrier to Induced Pluripotent Stem Cell Reprogramming

Miles DC. et al, (2017), STEM CELLS, 35, 147 - 157

Replication fork stability confers chemoresistance in BRCA-deficient cells

Ray Chaudhuri A. et al, (2016), Nature, 535, 382 - 387

Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer

Henneman L. et al, (2015), Proceedings of the National Academy of Sciences, 112, 8409 - 8414

REV7 counteracts DNA double-strand break resection and affects PARP inhibition.

Xu G. et al, (2015), Nature, 521, 541 - 544

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