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CLINICAL QUESTION: Does transfusing platelets to preterm infants (< 34 weeks) at a higher platelet count threshold count (< 50 x 109 /L) reduce the risk of major bleeding or death compared to only transfusing platelets when the platelet count drops below 25 x 109 /L. EVIDENCE FROM TRIAL: Preterm infants with a low platelet count who were transfused platelets at the higher platelet count threshold had a higher risk of dying or having a major bleed than those who were not. The reasons why this occurred are currently unclear.

Original publication




Journal article


Transfus Med

Publication Date





20 - 22


neonate, platelet transfusion, thrombocytopenia, Female, Hemorrhage, Humans, Infant, Newborn, Infant, Premature, Male, Platelet Transfusion, Thrombocytopenia