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Recent work has shown that a major population of murine influenza A specific cytotoxic T lymphocytes (CTL) recognize the viral nucleoprotein. In order to investigate the mechanism by which this nonglycoprotein component of the virus is recognized by CTL, a series of deletion mutants of an A virus NP gene were studied. The results showed that CTL recognize three distinct epitopes of the NP molecule. Both N- and C-terminal fragments of the protein are transported, independently of each other, to the site of recognition by CTL. These findings imply that a mechanism may exist for transport to the cell surface and presentation to CTL, of viral proteins and protein fragments that lack defined signal sequences.

Type

Journal article

Journal

Cell

Publication Date

09/1985

Volume

42

Pages

457 - 467

Keywords

Animals, Antigens, Viral, Clone Cells, Epitopes, Genes, Viral, H-2 Antigens, Influenza A virus, L Cells (Cell Line), Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Mutation, Nucleoproteins, Recombination, Genetic, T-Lymphocytes, Cytotoxic, Transcription, Genetic, Transfection, Viral Proteins