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Some Kelch mutations of the Plasmodium falciparum K13 protein confer increased survival to dihydroartemisinin (DHA)-treated ring-stage parasites. Here, we asked if K13 mutations affect a dormancy phenotype allowing parasites to survive DHA exposure and then sorbitol selection. Although recrudescence from dormancy differed between two distinct parasite lines, it was similar for isogenic lines carrying single-site substitutions in K13. Therefore, K13 mutations do not alter the DHA-sorbitol combined dormancy phenotype; rather, traits from other loci likely determine this phenotype.

Original publication

DOI

10.1128/AAC.02256-17

Type

Journal article

Journal

Antimicrob Agents Chemother

Publication Date

05/2018

Volume

62

Keywords

drug resistance, malaria, recrudescence, Animals, Antimalarials, Artemisinins, Drug Resistance, Mutation, Plasmodium falciparum, Polymorphism, Genetic, Sorbitol