Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

A critical role of pattern recognition receptors (PRRs) is to influence adaptive immune responses by regulating antigen presentation. Engagement of PRRs in dendritic cells (DCs) increases MHC class I antigen presentation and CD8+ T-cell activation by cross-presented peptides but the molecular mechanisms underlying these effects are not completely understood. Studies looking at the role of PRRs in cross-presentation have been largely limited to TLRs but the role of other PRRs such as cytosolic nucleotide-binding oligomerization domain-like (NOD-like) receptors remains particularly enigmatic. Here we discuss recent evidence of the role of PRRs on cross-presentation and consider how cytosolic NLR-associated pathways, such as NOD2, may integrate these signals resulting in effective adaptive CD8+ T cells responses.

Original publication

DOI

10.1016/j.molimm.2017.11.028

Type

Journal article

Journal

Mol Immunol

Publication Date

09/2019

Volume

113

Pages

6 - 10

Keywords

CD8+ T cells, Cross-presentation, MHC class I, NLRs, PRRs, Animals, CD8-Positive T-Lymphocytes, Cross-Priming, Humans, Immunity, Innate, NLR Proteins, Receptors, Pattern Recognition, Signal Transduction