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Clinical Question: Are pathogen-reduced platelets as effective as standard platelets for the prevention of bleeding in people of any age requiring platelet transfusions? Bottom Line: In people with cancer who have a low platelet count due to their disease or its treatment, pathogen-reduced platelet transfusions increase risk of platelet refractoriness and platelet transfusion requirement (high-quality evidence) but probably do not effect all-cause mortality, risk of clinically significant or severe bleeding, or risk of a serious adverse event (moderate-quality evidence). There was insufficient evidence for people with other diagnoses.

Original publication




Journal article


JAMA Oncol

Publication Date





571 - 572


Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Blood Safety, Child, Child, Preschool, Disease Transmission, Infectious, Disinfection, Hemorrhage, Humans, Middle Aged, Neoplasms, Platelet Transfusion, Thrombocytopenia, Young Adult