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One hundred seventy-six consecutive patients treated with IV tissue plasminogen activator (tPA) for acute ischemic stroke were examined prospectively, and orolingual angioedema was found in nine (5.1%; 95% CI 2.3 to 9.5). The reaction was typically mild, transient, and contralateral to the ischemic hemisphere. Risk of angioedema was associated with angiotensin-converting enzyme inhibitors (relative risk [RR] 13.6; 95% CI 3.0 to 62.7) and signs on initial CT of ischemia in the insular and frontal cortex (RR 9.1; 95% CI 1.4 to 30.0).

Original publication




Journal article



Publication Date





1525 - 1527


Aged, Alberta, Angioedema, Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Bradykinin, Brain Ischemia, Cerebral Cortex, Drug Synergism, Female, Fibrinolytic Agents, Frontal Lobe, Humans, Lysine Carboxypeptidase, Male, Mouth, Prospective Studies, Stroke, Tissue Plasminogen Activator, Tongue