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We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.

Original publication

DOI

10.1038/ng.639

Type

Journal article

Journal

Nat Genet

Publication Date

09/2010

Volume

42

Pages

739 - 741

Keywords

Case-Control Studies, Chromosomes, Human, Pair 18, Gambia, Genetic Loci, Genetic Predisposition to Disease, Genetics, Population, Genome-Wide Association Study, Ghana, Humans, Linkage Disequilibrium, Odds Ratio, Polymorphism, Single Nucleotide, Tuberculosis