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An understanding of how to counteract the anticoagulant effect of direct oral anticoagulants is essential in the event of haemorrhage, emergency surgery and overdose. This review summarizes strategies for the reversal of direct oral anticoagulants, including the use of novel agents.

Original publication

DOI

10.12968/hmed.2017.78.3.165

Type

Journal article

Journal

Br J Hosp Med (Lond)

Publication Date

02/03/2017

Volume

78

Pages

165 - 169

Keywords

Aged, Antibodies, Monoclonal, Humanized, Anticoagulants, Antidotes, Antithrombins, Arginine, Blood Coagulation Factors, Coagulants, Dabigatran, Factor Xa, Factor Xa Inhibitors, Hemorrhage, Humans, Intracranial Hemorrhages, Male, Partial Thromboplastin Time, Piperazines, Prothrombin Time, Recombinant Proteins, Thrombin Time