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The conserved epitopes of influenza nucleoprotein (NP) recognized by class I MHC-restricted CTL from CBA (H-2k) and C57BL/10 (H-2b) mice have been defined in vitro with synthetic peptides 50-63 and 365-379, respectively. Two Db-restricted clones were described that recognize different epitopes on peptide 365-379. Finally, the recognition of complete NP was shown to be approximately 200-fold less efficient than peptide in the cytotoxicity assay. These phenomena are closely related to results with class II-restricted T cells and they strengthen the hypothesis that influenza proteins are degraded in the infected cell before recognition by class I-restricted CTL.

Type

Journal article

Journal

J Exp Med

Publication Date

01/06/1987

Volume

165

Pages

1508 - 1523

Keywords

Amino Acid Sequence, Animals, Cytotoxicity Tests, Immunologic, Epitopes, Female, Histocompatibility Antigens, Influenza A virus, Mice, Mice, Inbred C57BL, Nucleoproteins, T-Lymphocytes, Cytotoxic, Viral Proteins