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The Runx family of transcription factors (Runx1, Runx2, and Runx3) are highly conserved and encode proteins involved in a variety of cell lineages, including blood and blood-related cell lineages, during developmental and adult stages of life. They perform activation and repressive functions in the regulation of gene expression. The requirement for Runx1 in the normal hematopoietic development and its dysregulation through chromosomal translocations and loss-of-function mutations as found in acute myeloid leukemias highlight the importance of this transcription factor in the healthy blood system. Whereas another review will focus on the role of Runx factors in leukemias, this review will provide an overview of the normal regulation and function of Runx factors in hematopoiesis and focus particularly on the biological effects of Runx1 in the generation of hematopoietic stem cells. We will present the current knowledge of the structure and regulatory features directing lineage-specific expression of Runx genes, the models of embryonic and adult hematopoietic development that provide information on their function, and some of the mechanisms by which they affect hematopoietic function.

Original publication

DOI

10.1182/blood-2016-12-689109

Type

Journal article

Journal

Blood

Publication Date

13/04/2017

Volume

129

Pages

2061 - 2069

Keywords

Acute Disease, Animals, Core Binding Factor Alpha 2 Subunit, Gene Expression Regulation, Leukemic, Hematopoiesis, Hematopoietic Stem Cells, Humans, Leukemia, Mutation, Neoplasm Proteins