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The human tropomyosin 3 (TPM3) gene was previously localized to chromosome 1. The non-muscle isoform of the TPM3 gene product becomes fused to a gene product from the tyrosine kinase receptor gene (NTRK1), previously localized to 1q23-->q24, to generate an active oncogene. Two sequence tagged sites spanning three exons and two introns in the carboxy coding region of the gene were used to localize TPM3 to 1q22-->q23 by fluorescence in situ hybridization. This localization now places the NTRK1 and TPM3 genes in close proximity, so that a gene fusion rearrangement would not be cytologically detected. The 1q22-->q23 localization of TPM3 is within the NEM1 locus associated with autosomal dominant nemaline myopathy, making TPM3 a candidate for this disorder.

Type

Journal article

Journal

Cytogenet Cell Genet

Publication Date

1995

Volume

68

Pages

122 - 124

Keywords

Animals, Base Sequence, Chromosome Mapping, Chromosomes, Human, Pair 1, DNA Primers, Exons, Hominidae, Humans, In Situ Hybridization, Fluorescence, Introns, Male, Molecular Sequence Data, Oncogenes, Proto-Oncogene Proteins, Receptor Protein-Tyrosine Kinases, Receptor, trkA, Receptors, Nerve Growth Factor, Reference Values, Sequence Tagged Sites, Tropomyosin