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Saphenous vein graft (SVG) disease and subsequent vein graft failure remain a major problem after coronary artery bypass graft operations. In an effort to mitigate loss of endothelial viability, the vein is stored, intraoperatively, in a preservation solution. However, human SVG samples demonstrate endothelial denudation and dysfunction after such storage, the severity of which varies, depending on the medium. The paucity of clinical data evaluating preservation solutions is illustrated by the absence of optimal procedural protocol. This review evaluates the potential efficacy of different storage solutions in preserving vein grafts, in relation to a mechanistic understanding of SVG pathophysiology.

Original publication

DOI

10.1016/j.athoracsur.2016.05.097

Type

Journal article

Journal

Ann Thorac Surg

Publication Date

11/2016

Volume

102

Pages

1736 - 1746

Keywords

Coronary Angiography, Coronary Artery Bypass, Coronary Artery Disease, Graft Occlusion, Vascular, Humans, Intraoperative Period, Organ Preservation, Saphenous Vein