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Consolidation with high-dose chemotherapy and autologous stem cell transplantation (ASCT) is the standard of care for transplantation-eligible patients with multiple myeloma, based on randomized trials showing improved progression-free survival with autologous transplantation after combination chemotherapy induction. These trials were performed before novel agents were introduced; subsequently, combinations of immunomodulatory drugs and proteasome inhibitors as induction therapy have significantly improved rates and depth of response. Ongoing randomized trials are testing whether conventional autologous transplantation continues to improve responses after novel agent induction. Although these results are awaited, it is important to review strategies for improving outcomes after ASCT. Conditioning before ASCT with higher doses of melphalan and combinations of melphalan with other agents, including radiopharmaceuticals, has been explored. Tandem ASCT, consolidation, and maintenance therapy after ASCT have been investigated in phase III trials. Experimental cellular therapies using ex vivo-primed dendritic cells, ex vivo-expanded autologous lymphocytes, Killer Immunoglobulin Receptor (KIR)-mismatched allogeneic natural killer cells, and genetically modified T cells to augment ASCT are also in phase I trials. This review summarizes these strategies and highlights the importance of exploring strategies to augment ASCT, even in the era of novel agent induction.

Original publication

DOI

10.1016/j.bbmt.2016.06.004

Type

Journal article

Journal

Biol Blood Marrow Transplant

Publication Date

11/2016

Volume

22

Pages

1926 - 1937

Keywords

Conditioning, Immunotherapy, Minimal residual disease, Multiple myeloma, Stem cell transplantation, Antineoplastic Combined Chemotherapy Protocols, Humans, Immunotherapy, Adoptive, Multiple Myeloma, Stem Cell Transplantation, Transplantation Conditioning, Transplantation, Autologous, Treatment Outcome