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Patients with hematologic malignancies frequently become thrombocytopenic as a result of their underlying malignancy or treatments, including cytotoxic chemotherapy and hematopoietic stem cell transplantation and are at increased risk of hemorrhage. Prophylactic platelet transfusions are aimed at preventing severe or life-threatening hemorrhage. This review summarizes recent evidence, including the need for prophylactic platelet transfusions, the optimal dose, platelet transfusion triggers, and risk factors for bleeding. It also discusses controversies surrounding platelet transfusions in this population.

Original publication

DOI

10.1016/j.hoc.2016.01.002

Type

Journal article

Journal

Hematol Oncol Clin North Am

Publication Date

06/2016

Volume

30

Pages

541 - 560

Keywords

Acute leukemia, Bleeding, Chemotherapy, Hematopoietic stem cell transplantation, Platelet transfusion, Thrombocytopenia, Allografts, Clinical Trials as Topic, Hematopoietic Stem Cell Transplantation, Hemorrhage, Humans, Neoplasms, Platelet Transfusion, Risk Factors, Thrombocytopenia