Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

To gain insight into potential regulatory mechanisms through which the effects of variants at four established type 2 diabetes (T2D) susceptibility loci (CDKAL1, CDKN2A-B, IGF2BP2 and KCNQ1) are mediated, we undertook transancestral fine-mapping in 22 086 cases and 42 539 controls of East Asian, European, South Asian, African American and Mexican American descent. Through high-density imputation and conditional analyses, we identified seven distinct association signals at these four loci, each with allelic effects on T2D susceptibility that were homogenous across ancestry groups. By leveraging differences in the structure of linkage disequilibrium between diverse populations, and increased sample size, we localised the variants most likely to drive each distinct association signal. We demonstrated that integration of these genetic fine-mapping data with genomic annotation can highlight potential causal regulatory elements in T2D-relevant tissues. These analyses provide insight into the mechanisms through which T2D association signals are mediated, and suggest future routes to understanding the biology of specific disease susceptibility loci.

Original publication

DOI

10.1093/hmg/ddw048

Type

Journal article

Journal

Hum Mol Genet

Publication Date

15/05/2016

Volume

25

Pages

2070 - 2081

Keywords

African Americans, Alleles, Asian Continental Ancestry Group, Chromosome Mapping, Cyclin-Dependent Kinase Inhibitor p18, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Female, Genetic Association Studies, Genetic Predisposition to Disease, Humans, KCNQ1 Potassium Channel, Linkage Disequilibrium, Male, Polymorphism, Single Nucleotide, RNA-Binding Proteins, Regulatory Elements, Transcriptional, tRNA Methyltransferases