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Variation in the immunodominant T cell epitopes Th2R and Th3R of the Plasmodium falciparum circumsporozoite protein has been analysed from Gambian clinical isolates using the polymerase chain reaction. The degree of polymorphism in these epitopes is more extensive than that found in several geographically diverse laboratory isolates. These findings strongly suggest that it will not be feasible to include all variants in a polyvalent subunit sporozoite vaccine.

Type

Journal article

Journal

Mol Biochem Parasitol

Publication Date

12/1989

Volume

37

Pages

275 - 280

Keywords

Amino Acid Sequence, Animals, Antigens, Protozoan, Base Sequence, DNA, Epitopes, Molecular Sequence Data, Plasmodium falciparum, Polymerase Chain Reaction, Polymorphism, Genetic, Protozoan Proteins, T-Lymphocytes