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Copper-catalyzed Si-H, B-H, P-H, S-H, and N-H insertion reactions of 2,2,2-trifluoro-1-diazoethane and 1-aryl 2,2,2-trifluorodiazoethanes generated a large number of new fluorine-containing chemical entities for medicinal chemists. With selected Si-H and B-H insertion reactions, we demonstrate successful extension to asymmetric catalysis.

Original publication

DOI

10.1002/anie.201511954

Type

Journal article

Journal

Angew Chem Int Ed Engl

Publication Date

07/03/2016

Volume

55

Pages

3785 - 3789

Keywords

asymmetric catalysis, carbenes, copper catalysis, diazo compounds, heteroatom-hydrogen insertion