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How is β-cell mass adjusted to changes in the functional insulin requirements? The answer to this question is central to the understanding of the causes and (potentially) the therapy of type 2 diabetes. In this issue of Cell Metabolism, El Ouaamari et al. (2016) report that increased production of the protease inhibitor SerpinB1 in the liver links insulin resistance to stimulation of β-cell proliferation.

Original publication

DOI

10.1016/j.cmet.2015.12.011

Type

Journal article

Journal

Cell Metab

Publication Date

12/01/2016

Volume

23

Pages

8 - 10

Keywords

Diabetes Mellitus, Type 2, Humans, Insulin, Insulin Resistance, Insulin-Secreting Cells, Liver